Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is used to make pharmaceuticals and intermediates.
The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.
Applications in Pharmaceuticals
The ester is a KRM for the manufacture of APIs:
|Ronidazole, an antibiotic|
|Tenofovir, an anti-HIV drug|
|Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid|
|Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A|
Applications in Intermediates
Chloromethyl chloroformate forms a variety of intermediates such as:
|Chloromethyl ethyl carbonate|
|Chloromethyl isopropyl carbonate|
|Appearance||–||Clear colorless to yellow liquid|
|Solubility||–||Should be soluble in dichloromethane|
|Identification by FTIR||–||Should conform to the structure|
|Chromatographic purity by GC||%||Min 98.0|
|Dichloromethyl chloroformate by NMR||%||Max 1.0|
Recommended storage temperature is 2° to 8°C.
25 kg UN approved drum
ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
L-Alpha glycerylphosphorylcholine (alpha-GPC or choline alfoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction.
3,3,3-Trifluoropropanol is a colorless liquid that is consumed in manufacture of value-added intermediates. This apart, the halogenated alcohol is also cited to have applications in other industry verticals. It also finds uses in proteomic research and in agrochemicals.
Calcium Gluconate is the calcium salt of gluconic acid, an oxidation product of glucose, and contains 9.3% calcium, which is about one-third of the calcium in the strength of calcium chloride. It is an ingredient found in a variety of supplements and vitamins and is used to lower potassium in the blood.
2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.
Sodium Alginate is a linear polysaccharide derivative of alginic acid processed from brown algae. The conversion of alginic acid to sodium alginate allows its solubility in water, which assists its extraction. Sodium Alginate is used as a hydrocolloid in various applications such as food manufacturing and pharmaceuticals, as an emulsifier in textiles and cosmetics industries and in dentistry to make molds.
Chromium hydroxide, a gelatinous, polymeric inorganic powder, is amphoteric in nature. It reacts as an acid as well as a base. On heating, it decomposes to chromic oxide. The molecule is largely used in cosmetics and tanning industries.
Magnesium trisilicate is an inorganic compound that is used as a food additive. The additive is frequently used by fast food chains to absorb fatty acids and extract impurities formed while frying edible oils. It has good acid neutralizing properties.
1,3-Dihyrdoxyacetone is a hygroscopic, white powder with a minty odor. It is abundantly found in nature as derivative of starch and is an intermediate product of fructose metabolism. Acronymed as DHA, it is at large used in the cosmetic industry.
3-Chloroperoxybenzoic acid (MCPBA) is a peroxycarboxylic acid. A white solid, it is used widely as an oxidant in organic synthesis. MCPBA is often preferred to other peroxy acids because of its relative ease of handling.