INTRODUCTION

Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is  used to make pharmaceuticals and intermediates.

Manufacture

The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.

SynonymsChloromethoxycarbonyl chloride
Chloromethyl carbonochloridate
CAS no.22128-62-7
EINECS no.244-793-3
Molecular formulaC2H2Cl2O2
Molecular weight128.94
Structure

Applications in Pharmaceuticals

The ester is a KRM for the manufacture of APIs:

Ronidazole, an antibiotic
Tenofovir, an anti-HIV drug
Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid
Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A

Applications in Intermediates

Chloromethyl chloroformate forms a variety of intermediates such as:

Chloromethyl chlorosulphate
Methyl chlorosulphonate
Chloromethyl ethyl carbonate
Chloromethyl isopropyl carbonate
Carbamates

SPECIFICATIONS

TestUnitSpecification
AppearanceClear colorless to yellow liquid
SolubilityShould be soluble in dichloromethane
Identification by FTIRShould conform to the structure
Chromatographic purity by GC%Min 98.0
Dichloromethyl chloroformate by NMR%Max 1.0

STORAGE
Recommended storage temperature is 2° to 8°C.

PACKING
25 kg UN approved drum

ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.

More Prodcuts
In Focus:1-(Difluoromethyl)-4-nitro-1H-pyrazole
Products in focus · 26/09/2023

1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.

READ MORE
In Focus: 1-Bromohexane
Products in focus · 21/09/2023

1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.

READ MORE
In Focus: Valeryl chloride
Products in focus · 06/09/2023

Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.

READ MORE
In focus: 2-Chloroethylamine Hydrochloride
Products in focus · 29/08/2023

2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.

READ MORE
In focus: Thiophosgene
Products in focus · 23/08/2023

Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.

READ MORE
In focus: N,N’-Dicyclohexylcarbodiimide
Products in focus · 16/08/2023

N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure.

READ MORE
In focus: Sodium bromide
Products in focus · 08/08/2023

Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.

READ MORE
In focus: 3,5-Dibromo-4-hydroxybenzoic acid
Products in focus · 25/07/2023

3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.

READ MORE
In focus: Bakuchiol
Products in focus · 18/07/2023

Bakuchiol is known as Vegan Retinol as it has ability to improve uneven skin tone by reducing the appearance of dark spots and pigmentation. It is best in class of anti-aging and anti-wrinkles effect.

READ MORE