Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is used to make pharmaceuticals and intermediates.
The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.
Applications in Pharmaceuticals
The ester is a KRM for the manufacture of APIs:
|Ronidazole, an antibiotic|
|Tenofovir, an anti-HIV drug|
|Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid|
|Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A|
Applications in Intermediates
Chloromethyl chloroformate forms a variety of intermediates such as:
|Chloromethyl ethyl carbonate|
|Chloromethyl isopropyl carbonate|
|Appearance||–||Clear colorless to yellow liquid|
|Solubility||–||Should be soluble in dichloromethane|
|Identification by FTIR||–||Should conform to the structure|
|Chromatographic purity by GC||%||Min 98.0|
|Dichloromethyl chloroformate by NMR||%||Max 1.0|
Recommended storage temperature is 2° to 8°C.
25 kg UN approved drum
ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Potassium borohydride (KBH4) is an inorganic chemical with unique reducing power that is used in chemical synthesis. Whereas it easily generates a hydrogen atom quintessential for reduction processes, the borohydride reacts violently with water. It is toxic by ingestion. KBH4 finds large consumption in agrochemicals, pharmaceuticals, and intermediates.
Curcumin is a bright yellow chemical produced by plants of the Curcuma longa species. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.
Triphenyl phosphite (TPP) is an organophos-phorous compound and is a colorless, viscous liquid with high boiling point. It possesses a characteristic, delicate fragrance. Its uses can be found largely in polymers. Besides, it participates as a reactant in organic syntheses.
Lithium bromide (LiBr) is a white, hygroscopic solid. The hygroscopic nature makes it a versatile chemical that can be put to various end uses. It is usually sold in anhydrous form or in aqueous solutions of varying concentrations.
Valeraldehyde, an aliphatic compound, is a colorless liquid with intense, clinging odor. It is naturally abundant in many essential oils. Apart from being an aroma chemical itself, it is applied to synthesize downstream products that are F&F chemicals and intermediates.
Pyruvic acid is a yellowish liquid with vinegar odor. Anatomically, it participates in biological synthesis and metabolic processes of carbohydrates, amino acids, and lipids. Its reactivity is attributed to the presence of two carbonyl groups adjacent to each other and thus the chemical is employed in many synthesis processes leading a variety of end-uses.
2-Amino-p-cresol is a crystalline, sublime solid soluble in oxygenated solvents. It serves as an important starting material for production of colorants and other intermediates.
What is soy lecithin? Lecithin is a food additive that comes from several sources – one of them being soy. It’s generally used as an emulsifier, or lubricant, when added to food, but also has uses as an antioxidant and flavor protector.
Oxalyl chloride is a colorless liquid with pungent odor. The chloride is volatile and moisture sensitive. As a useful reagent employed in a variety of chemical syntheses, it finds applications in APIs, intermediates, and agrochemicals.