INTRODUCTION
Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is used to make pharmaceuticals and intermediates.
Manufacture
The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.
| Synonyms | Chloromethoxycarbonyl chloride Chloromethyl carbonochloridate |
| CAS no. | 22128-62-7 |
| EINECS no. | 244-793-3 |
| Molecular formula | C2H2Cl2O2 |
| Molecular weight | 128.94 |
| Structure |  |
Applications in Pharmaceuticals
The ester is a KRM for the manufacture of APIs:
| Ronidazole, an antibiotic |
| Tenofovir, an anti-HIV drug |
| Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid |
| Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A |
Applications in Intermediates
Chloromethyl chloroformate forms a variety of intermediates such as:
| Chloromethyl chlorosulphate |
| Methyl chlorosulphonate |
| Chloromethyl ethyl carbonate |
| Chloromethyl isopropyl carbonate |
| Carbamates |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to yellow liquid |
| Solubility | – | Should be soluble in dichloromethane |
| Identification by FTIR | – | Should conform to the structure |
| Chromatographic purity by GC | % | Min 98.0 |
| Dichloromethyl chloroformate by NMR | % | Max 1.0 |
STORAGE
Recommended storage temperature is 2° to 8°C.
PACKING
25 kg UN approved drum
ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.
Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Bakuchiol is known as Vegan Retinol as it has ability to improve uneven skin tone by reducing the appearance of dark spots and pigmentation. It is best in class of anti-aging and anti-wrinkles effect.