INTRODUCTION
Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is used to make pharmaceuticals and intermediates.
Manufacture
The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.
| Synonyms | Chloromethoxycarbonyl chloride Chloromethyl carbonochloridate |
| CAS no. | 22128-62-7 |
| EINECS no. | 244-793-3 |
| Molecular formula | C2H2Cl2O2 |
| Molecular weight | 128.94 |
| Structure |  |
Applications in Pharmaceuticals
The ester is a KRM for the manufacture of APIs:
| Ronidazole, an antibiotic |
| Tenofovir, an anti-HIV drug |
| Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid |
| Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A |
Applications in Intermediates
Chloromethyl chloroformate forms a variety of intermediates such as:
| Chloromethyl chlorosulphate |
| Methyl chlorosulphonate |
| Chloromethyl ethyl carbonate |
| Chloromethyl isopropyl carbonate |
| Carbamates |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to yellow liquid |
| Solubility | – | Should be soluble in dichloromethane |
| Identification by FTIR | – | Should conform to the structure |
| Chromatographic purity by GC | % | Min 98.0 |
| Dichloromethyl chloroformate by NMR | % | Max 1.0 |
STORAGE
Recommended storage temperature is 2° to 8°C.
PACKING
25 kg UN approved drum
ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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