INTRODUCTION

Chloromethyl chloroformate is a colorless liquid, which was earlier employed in its gaseous form as warfare chemical under the name Palite gas. In chemicals industry, for its extreme reactivity, it is  used to make pharmaceuticals and intermediates.

Manufacture

The chloroformic acid ester is produced by allylic chlorination of methyl chloroformate, which in turn is formed by reaction of methanol with phosgene.

SynonymsChloromethoxycarbonyl chloride
Chloromethyl carbonochloridate
CAS no.22128-62-7
EINECS no.244-793-3
Molecular formulaC2H2Cl2O2
Molecular weight128.94
Structure

Applications in Pharmaceuticals

The ester is a KRM for the manufacture of APIs:

Ronidazole, an antibiotic
Tenofovir, an anti-HIV drug
Aminocarbonyloxymethyl ester of Diclofenac and Flufenamic Acid
Monomethoxypoly(ethylene glycol) prodrug of Cyclosporine A

Applications in Intermediates

Chloromethyl chloroformate forms a variety of intermediates such as:

Chloromethyl chlorosulphate
Methyl chlorosulphonate
Chloromethyl ethyl carbonate
Chloromethyl isopropyl carbonate
Carbamates

SPECIFICATIONS

TestUnitSpecification
AppearanceClear colorless to yellow liquid
SolubilityShould be soluble in dichloromethane
Identification by FTIRShould conform to the structure
Chromatographic purity by GC%Min 98.0
Dichloromethyl chloroformate by NMR%Max 1.0

STORAGE
Recommended storage temperature is 2° to 8°C.

PACKING
25 kg UN approved drum

ExSyn offers chloromethyl chloroformate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.

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