INTRODUCTION
Cetylpyridinium chloride is the chloride salt form of cetylpyridinium, a quaternary ammonium with broad-spectrum antimicrobial activity. Upon topical administration, cetylpyridinium chloride is positively charged and reacts with the negatively charged microbial cell surfaces, thereby destroying the integrity of the cell membrane.
MANUFACTURE
The process involves reacting cetyl chloride with pyridine under nitrogen atmosphere in an autoclave pressure followed by agitation.
| Synonym | Hexadecylpyridinium chloride monohydrate |
| CAS no. | 6004-24-6 |
| EINECS No | 204-593-9 |
| Molecular formula | C21H38ClN · H2O |
| Molecular weight | 358.00 g/mol |
| Structure |  |
APPLICATIONS
| Used as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis. |
| Used on raw and fully cooked foods including, poultry, red meat, fish and shellfish, eggs, fruits, vegetables, cereal grains, nutmeats, and dairy products as an antimicrobial agent at levels not to exceed 1.0%. |
| It has also been used as an ingredient in certain pesticides. |
SPECIFICATIONS…USP
| Test | Unit | Specification |
|---|---|---|
| Description | – | White to almost-white powder, having a slight, characteristic odour. |
| Solubility | – | Very soluble in water, alcohol and chloroform; slightly soluble in benzene and ether. |
| Identification | To comply with USP tests (A,B & C) | |
| A. IR test | – | Positive |
| B. HPLC test | – | Positive |
| C. Chloride test | – | Positive |
| Acidity | – | Not more than 2.5 ml of 0.02N NaOH solution is required for neutralization. |
| Residue on ignition | % | NMT 0.20 |
| Organic impurities | ||
| 1. Myristylpyridinium | % | NMT 0.45 |
| 2. Stearylpyridinium | % | NMT 0.15 |
| 3. Any unspecified Impurity | % | NMT 0.1 |
| 4.Total impurities | % | NMT 1.0 |
| Water determination | % | 4.5 to 5.5 |
| Assay (on anhydrous basis) | % | Cetyl pyridinium chloride contains NLT 98.0 and NMT 102.0 of C21H38ClN. |
PACKING
25 kg Fiber drum.
STORAGE
Keep containers tightly closed in a dry, cool and well-ventilated place. Store at room temperature.
CERTIFICATION
WHO-GMP and WC
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Nicotinamide riboside chloride (NRCL) is a unique form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, it has sparked interest in the realms of aging, metabolism, and overall cellular health.
Tetrachlorvinphos (popularly known as TCVP) is an agrochemical belonging to class of organophosphates. It is a non-systemic insecticide and acaracide having widespread uses in crop protection, public health, and animal hygiene.
Sodium Starch Glycolate (SSG) is a very fine free flowing powder that is white or off white in color and has almost no odor. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. It is a sodium salt of carboxyl ether of starch and is appreciated for its stability and binding properties.
3-([Ethyl(3-methylphenyl)amino]methyl) benzenesulfonic acid is an organic sulfonic acid, a white crystalline solid, which is widely used as a catalyst, acidifying agent, and a reagent in organic synthesis.
Sodium trifluoroacetate is a colorless organic solid belonging to category of fluoro compounds. It acts as a versatile trifluoromethylation agent in chemicals synthesis and is used to produce an array of chemical intermediates.
Iodopropynyl butylcarbamate, also known as IPBC, is an antimicrobial ingredient commonly used in cosmetics. It appears as a white, crystalline powder. It is not a paraben; it belongs to a different chemical class called carbamates. It is soluble in both water and oil-based systems. IPBC was invented in the 1970s and has a long history of effective use as an antifungal technology.
Stevia extract with Rebaudioside A (98%) is one of the sweet tasting steviol glycoside, extracted and purified from Stevia rebaudiana (Bertoni) – a small perennial shrub also known as “Honey leaf”. The leaves of S. rebaudiana contain more than 30 different steviol glycosides, among which stevioside and rebaudioside A are present in the highest levels. It is non-nutritive and tastes approximately 200-300 times sweeter than sucrose.
Protoporphyrin IX dimethyl ester, abbreviated PPMX, is an organic moiety belonging to category porphyrins. On exposure to light, PPMX releases reactive oxygen that can be used to destroy targeted cancer cells and thus it find applications largely in medicines.
N2-Isobutyryl-2′-O-methyl-guanosine (IBG) is a modified nucleoside that has gained significant attention in recent years due to its potential therapeutic and industrial applications. IBG is a derivative of guanosine, a nucleoside that is a building block of RNA and DNA.