Cetylpyridinium chloride is the chloride salt form of cetylpyridinium, a quaternary ammonium with broad-spectrum antimicrobial activity. Upon topical administration, cetylpyridinium chloride is positively charged and reacts with the negatively charged microbial cell surfaces, thereby destroying the integrity of the cell membrane.


The process involves reacting cetyl chloride with pyridine under nitrogen atmosphere in an autoclave pressure followed by agitation.

SynonymHexadecylpyridinium chloride monohydrate
CAS no.6004-24-6
EINECS No204-593-9
Molecular formulaC21H38ClN · H2O
Molecular weight358.00 g/mol


Used as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.
Used on raw and fully cooked foods including, poultry, red meat, fish and shellfish, eggs, fruits, vegetables, cereal grains, nutmeats, and dairy products as an antimicrobial agent at levels not to exceed 1.0%.
It has also been used as an ingredient in certain pesticides.


DescriptionWhite to almost-white powder, having a slight, characteristic odour.
SolubilityVery soluble in water, alcohol and chloroform; slightly soluble in benzene and ether.
IdentificationTo comply with USP tests (A,B & C)
A. IR testPositive
B. HPLC testPositive
C. Chloride testPositive
AcidityNot more than 2.5 ml of 0.02N NaOH solution is required for neutralization.
Residue on ignition%NMT 0.20
Organic impurities
1. Myristylpyridinium%NMT 0.45
2. Stearylpyridinium%NMT 0.15
3. Any unspecified Impurity%NMT 0.1
4.Total impurities%NMT 1.0
Water determination%4.5 to 5.5
Assay (on anhydrous basis)%Cetyl pyridinium chloride contains NLT 98.0 and NMT 102.0 of C21H38ClN.


25 kg Fiber drum.


Keep containers tightly closed in a dry, cool and well-ventilated place. Store at room temperature.



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