INTRODUCTION

N2-Isobutyryl-2′-O-methyl-guanosine (IBG) is a modified nucleoside that has gained significant attention in recent years due to its potential therapeutic and industrial applications. IBG is a derivative of guanosine, a nucleoside that is a building block of RNA and DNA.

Manufacture

By alkylation of O6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine.

SynonymN-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
CAS no.63264-29-9
Molecular formulaC15H21N5O6
Molecular weight367.36 g/mol
Structure

APPLICATIONS

N2-isobutyryl-2′-OMe-guanosine (IBG) has potential applications as follows:
It’s a modified nucleoside that can be used as an activator for DNA synthesis.
A useful intermediate in the synthesis and probes of novel nucleic acids.
Detecting DNA/RNA changes is the popular use of this fluorescent chemical.
Medical Research : IBG has been studied for its role in drug development, with promising results in preclinical studies.
Clinical Trials : IBG has also been studied in clinical trials for its potential therapeutic effects in various diseases, including viral infections and cancer. 
Environmental research – It has been studied for its effects on ecosystems and its potential role in pollution management.
Industrial research – IBG has been used in manufacturing processes to improve product quality and efficiency, with health and safety considerations being a major concern.

SPECIFICATIONS

TestUnitSpecifications
AppearanceWhite to off-white powder
1HNMRTo conform the structure
MSTo conform the structure
Purity by HPLC%≥ 98.0
Assay (by QNMR)%≥ 97%
Solvent content by GC%≤ 3.0
Water content%≤ 3.0

PACKING

25 kg HDPE drum with inner liner

STORAGE

Recommended storage between 2°C to 8°C

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