INTRODUCTION

Acetonitrile (ACN) is a highly polar, volatile, colorless liquid with ethereal odor and is the simplest organic nitrile widely used as a solvent.

The nitrile group constitutes active part of the molecule. It participates in various reactions that lead to number of nitrogen containing organic molecules.

Manufacture
ACN is manufactured on large scale by addition of ammonia in propylene, acrylonitrile being the by-product.

SynonymsMethyl Cyanide
Cyanomethane
CAS no.75-05-8
EINECS no.200-835-2
Molecular formulaC2H3N
Molecular weight41.05
Structure

Industrial Applications

ACN has excellent solubilizing properties. These enable its use as a useful solvent in synthesis and purification processes of distillation and recrystallization.

Commonly occurring uses as solvent are in:

High pressure liquid chromatographic (HPLC) analysis as an eluent.
Butadiene extraction in Petro refineries.
Manufacture of insulin, vitamins, amino acids and photographic films.
Lithium batteries.
Non-aqueous reactions that employ AlCl3 and PCl3.
Manufacture of flame retardants.
Extraction of fatty acids from vegetable oil.
Chemical intermediate and solvent for perfumes.
Catalyst and component of transition-metal complex catalysts.
Solvent for DNA synthesis and Peptide sequencing.
Solvent for spinning synthetic fibers.
Casting and moulding plastics.

Intermediates

The nitrile group being reactive, ACN acts as a key raw material in production of:

Acetamidine hydrochloride
Acetoguanamine
β-Aminocrotononitrile
2,4-Dihydroxy acetophenone
2,6-Dihydroxy acetophenone
Geranonitrile
Malononitrile
Triethyl orthoacetate
Sulphapyrimidines
O,N-bis(trimethylsilyl)acetamide

Applications in APIs

As a key raw material in the early manufacturing stages of:

SulfisomidineAntibacterial
PyritinolNootropic
CromolynAntiasthma / Antiallergic
AlprazolamAnxiolytic
DiazoxideAntihypertensive / Hyperglycemia
TriazolamHypnotic

As an essential raw material in the ultimate synthesis step of:

AmantadineAntiviral / Antiparkinsonian
SulphaphenazoleAntibacterial

Agrochemicals

IsoxabenHerbicide

SPECIFICATIONS

TestUnitSpecification
AppearanceClear colorless liquid, free from extraneous matter.
Identification (By GC)Retention time of the main peak in the test sample chromatogram should match with that of the standard.
Purity (By GC)%Min 99.0
Moisture Content (By KF)%Max 0.2
MiscibilityMiscible with methanol.
Non-volatile matter %Max 0.1

REACH status
Acetonitrile offered by ExSyn is registered under EU REACH regulations.

STORAGE
Product is stored at ambient temperature.

PACKING
Drum & ISO-tank

ExSyn offers acetonitrile on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.

More Products
In focus: Pyrophosphoryl Chloride
Products in focus · 29/11/2022

Pyrophosphoryl chloride is colourless to pale yellow liquid, reasonably easy to handle. It reacts violently with water & miscible with most organic solvents.
It is used in pharmaceutical and other organic synthesis, as laser materials and electronic components.

READ MORE
In focus: Benzilic Acid Ethyl Ester
Products in focus · 22/11/2022

Benzilic acid ethyl ester is an oil organic liquid. Its reactivity is attributed to the presence of the hydroxyl group at alpha-position to the carboxylic acid group and hence it participates in various reactions leading to value-added intermediates and APIs.

READ MORE
In focus: Bromobenzene
Products in focus · 15/11/2022

Bromobenzene, an aryl halide, is a clear, colorless liquid with a pleasant odor. It is soluble in methanol and diethyl ether, and very slightly soluble in cold water.

READ MORE
In focus: Dibutyltin Dilaurate
Products in focus · 08/11/2022

Dibutyltin laurate is an organotin compound with oily appearance. The lauric acid ester is used in various industrial applications as catalyst.

READ MORE
In focus: Pyridine Hydrobromide
Products in focus · 01/11/2022

Pyridine hydrobromide is a white to off-white hygroscopic crystalline solid with melting point/freezing point of 216 °C to 219 °C. It is miscible in water. It used in many chemical synthesis studies.

READ MORE
In focus: Chrysanthemic acid
Products in focus · 25/10/2022

Chrysanthemic acid is a cyclic organic compound. The product occurs naturally in its ester form in pyrethrum flowers. It is also found as metabolite of pyrenthrins. The acid carries a sweet odor thereby enabling its uses in flavors and is used to synthesize agrochemicals as well.

READ MORE
In focus: Propionic Anhydride
Products in focus · 18/10/2022

Propionic Anhydride is a colorless liquid having a pungent odor and high boiling point. It is miscible with most organic solvents. It is soluble in both water and alcohol. It is a widely used reagent in organic synthesis as well as for producing specialty derivatives of cellulose.

READ MORE
In focus: 2-Cyclohexene-1-one
Products in focus · 11/10/2022

2-Cyclohexene-1-one is an organic intermediate used in synthesis of pharmaceuticals, agrochemicals, and fragrances. It is a ketone, or more precisely, an enone.

READ MORE
In focus: Colchicine
Products in focus · 04/10/2022

It is an alkaloid used in the symptomatic relief of pain in attacks of gouty arthritis, pseudogout, sarcodial arthritis, calcific tendinitis and to treat the inflammatory symptoms of Familial Mediterranean Fever.
It appears as odourless or nearly odourless pale yellow needles or powder that darkens on exposure to light.

READ MORE