INTRODUCTION

2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco.  Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.

Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar.  The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine.  Another industrial process uses formaldehyde, acetone, and ammonia.

Synonyms2,6-Dimethylpyridine
alpha,alpha’-dimethylpyridine
CAS no.108-48-5
EINECS no.203-587-3
Molecular formulaC7H9N
Molecular weight107.15
Structure

Applications in APIs

The dialkylated pyridine is a KRM for production of APIs:
Clopidol – a veterinary medicine, used as coccidiostat.
Cefpiramide acid – an antibiotic

Applications in Intermediates

Amongst many others, the following intermediates are synthesized from 2,6-lutidine:
2,6-Dimethylpiperidine
Dipicolinic acid
2,6-Dimethylpyridine-4-amine
2-Bromomethyl-6-methylpyridine
2,6-Dimethylpyridine-N-oxide

Other Applications

As a sterically hindered mild base in organic syntheses
Used as food additive to impart nutty odor and flavor
Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries

SPECIFICATIONS

TestUnitSpecification
AppearanceMonophase clear colorless liquid with no foreign impurities
SolubilitySoluble in methanol and cold water
Boiling point°C144-145
ColorAPHAMax 20
Moisture by KF%Max 0.2
Identification by IRIR spectrum of the sample to be concordant with standard spectrum
Purity by GC%Min 99.0

STORAGE
The product is stored at ambient temperature.

PACKING
190 kg UN-approved HDPE drum.

REACH Status
Not registered yet.

ExSyn offers 2,6-lutidine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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