INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
CAS no. | 108-48-5 |
EINECS no. | 203-587-3 |
Molecular formula | C7H9N |
Molecular weight | 107.15 |
Structure | ![]() |
Applications in APIs
The dialkylated pyridine is a KRM for production of APIs: |
---|
Clopidol – a veterinary medicine, used as coccidiostat. |
Cefpiramide acid – an antibiotic |
Applications in Intermediates
Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
---|
2,6-Dimethylpiperidine |
Dipicolinic acid |
2,6-Dimethylpyridine-4-amine |
2-Bromomethyl-6-methylpyridine |
2,6-Dimethylpyridine-N-oxide |
Other Applications
As a sterically hindered mild base in organic syntheses |
Used as food additive to impart nutty odor and flavor |
Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | Monophase clear colorless liquid with no foreign impurities |
Solubility | – | Soluble in methanol and cold water |
Boiling point | °C | 144-145 |
Color | APHA | Max 20 |
Moisture by KF | % | Max 0.2 |
Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2,6-lutidine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.
Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Bakuchiol is known as Vegan Retinol as it has ability to improve uneven skin tone by reducing the appearance of dark spots and pigmentation. It is best in class of anti-aging and anti-wrinkles effect.