INTRODUCTION
2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.
Manufacture
The product is manufactured by ammonolysis of 2,6-difluorobenzonitrile.
| Synonyms | 6-Fluoroanthranilonitrile 6-Fluoro-2-aminobenzonitrile |
| CAS no. | 77326-36-4 |
| EINECS no. | 616-451-7 |
| Molecular formula | C7H5N2F |
| Molecular weight | 136.13 |
| Structure |  |
Applications in Medicine
| The halobenzonitrile is used to make medicinal products such as: |
|---|
| Novel Huprines |
| Tacrine-related compounds |
| Antifolates |
Applications in APIs
| The nitrile acts as a KRM in production of APIs such as: |
|---|
| Pazopanib |
| Dovitinib |
| Dovitinib lactic acid salt |
| Antibacterial quinazolines |
Applications in Intermediates
| A few important intermediates are also synthesized from 6-fluoroanthranilonitrile: |
|---|
| (4-Oxoquinazolin-2-yl)pyridine |
| 2-Amino-6-bromobenzonitrile |
| N-(2-cyano-3-fluorophenyl)pyrrole |
| 2-Fluoro-6-piperidinobenzonitrile |
| 2-Amino-6-fluorobenzoic acid |
| 5-Fluoro-1H-quinazoline-2,4-dione |
| 5-Fluoro-2,4-diaminoquinazoline |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Grey to light yellow solid |
| Purity | % | Min 99.0 |
| Moisture | % | Max 0.5 |
| Melting Range | °C | 120.0 – 128.0 |
STORAGE
The product is stored at ambient temperature
PACKING
25 kg drum
REACH Status
Not registered yet
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