INTRODUCTION
2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.
Manufacture
The product is manufactured by ammonolysis of 2,6-difluorobenzonitrile.
| Synonyms | 6-Fluoroanthranilonitrile 6-Fluoro-2-aminobenzonitrile |
| CAS no. | 77326-36-4 |
| EINECS no. | 616-451-7 |
| Molecular formula | C7H5N2F |
| Molecular weight | 136.13 |
| Structure |  |
Applications in Medicine
| The halobenzonitrile is used to make medicinal products such as: |
|---|
| Novel Huprines |
| Tacrine-related compounds |
| Antifolates |
Applications in APIs
| The nitrile acts as a KRM in production of APIs such as: |
|---|
| Pazopanib |
| Dovitinib |
| Dovitinib lactic acid salt |
| Antibacterial quinazolines |
Applications in Intermediates
| A few important intermediates are also synthesized from 6-fluoroanthranilonitrile: |
|---|
| (4-Oxoquinazolin-2-yl)pyridine |
| 2-Amino-6-bromobenzonitrile |
| N-(2-cyano-3-fluorophenyl)pyrrole |
| 2-Fluoro-6-piperidinobenzonitrile |
| 2-Amino-6-fluorobenzoic acid |
| 5-Fluoro-1H-quinazoline-2,4-dione |
| 5-Fluoro-2,4-diaminoquinazoline |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Grey to light yellow solid |
| Purity | % | Min 99.0 |
| Moisture | % | Max 0.5 |
| Melting Range | °C | 120.0 – 128.0 |
STORAGE
The product is stored at ambient temperature
PACKING
25 kg drum
REACH Status
Not registered yet
ExSyn offers 2-amino-6-fluorobenzonitrile on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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