INTRODUCTION

2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.

Manufacture
The product is manufactured by ammonolysis of 2,6-difluorobenzonitrile.

Synonyms6-Fluoroanthranilonitrile
6-Fluoro-2-aminobenzonitrile
CAS no.77326-36-4
EINECS no.616-451-7
Molecular formulaC7H5N2F
Molecular weight136.13
Structure

Applications in Medicine

The halobenzonitrile is used to make medicinal products such as:
Novel Huprines
Tacrine-related compounds
Antifolates

Applications in APIs

The nitrile acts as a KRM in production of APIs such as:
Pazopanib
Dovitinib
Dovitinib lactic acid salt
Antibacterial quinazolines

Applications in Intermediates

A few important intermediates are also synthesized from 6-fluoroanthranilonitrile:
(4-Oxoquinazolin-2-yl)pyridine
2-Amino-6-bromobenzonitrile
N-(2-cyano-3-fluorophenyl)pyrrole
2-Fluoro-6-piperidinobenzonitrile
2-Amino-6-fluorobenzoic acid
5-Fluoro-1H-quinazoline-2,4-dione
5-Fluoro-2,4-diaminoquinazoline

SPECIFICATIONS

TestUnitSpecification
AppearanceGrey to light yellow solid
Purity%Min 99.0
Moisture%Max 0.5
Melting Range°C120.0 – 128.0

STORAGE
The product is stored at ambient temperature

PACKING
25 kg drum

REACH Status
Not registered yet

ExSyn offers 2-amino-6-fluorobenzonitrile on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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