INTRODUCTION
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
Manufacture
It is manufactured by difluoromethylation of 4-nitro-1H-pyrazole.
| Synonym | N-difluoromethyl-4-nitropyrazole; 1H-Pyrazole, 1-(difluoromethyl)-4-nitro- |
| CAS No. | 956477-64-8 |
| EINECS No. | 818-063-5 |
| Molecular weight | 163.08 |
| Structure |  |
Applications
| APIS : 1-(Difluoromethyl)-4-nitro-1H-pyrazole is used in synthesis of the following APIS: |
|---|
| Heterocyclic p2′ groups as factor XIa inhibitors |
| NLRP3 inflammasome modulators for the treatment of inflammatory, autoinflammatory, autoimmune and neoplastic diseases |
| an FXIa inhibitor treating thromboembolic disorders |
| Milvexian- anticoagulant |
| Intermediates |
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| 1-(difluoromethyl)-1H-pyrazole-4amine |
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