INTRODUCTION
Trifluoroacetic anhydride is an organic liquid that belongs to the category of fluorochemicals. It is an anhydride of trifluoroacetic acid and has uses in APIs, intermediates, and agrochemicals. It is also a building block to introduce trifluoroacetyl group in organic moieties.
Manufacture
The anhydride is produced by dehydration of trifluoroacetic acid using phosphorous pentoxide or dichloroacetyl chloride.
| Synonyms | Perfluoroacetic anhydride TFAA |
| CAS no. | 407-25-0 |
| EINECS no. | 206-982-9 |
| Molecular formula | C4F6O3 |
| Molecular weight | 210.03 |
| Structure |  |
Applications
| APIs |
|---|
| Epirubicin, co-drug for breast cancer treatment |
| Intermediates |
|---|
| Bis(trifluoroacetoxyiodo)pentafluorobenzene |
| 2-Hydroxy-4-(trifluoroacetyl)pyrimidine |
| 2-(Methylmercapto)-4-(trifluoroacetyl)-pyrimidine |
| 5-Bromopyridine-2-carbaldehyde |
| Agrochemicals |
|---|
| Chlorfenapyr, a pesticide |
| Others |
|---|
| Building block to introduce trifluoroacetyl group in organic chemicals |
| Regioselective synthesis of nitroindoles |
| Synthesis of alpha-seleno boronates |
| Bioplastic synthesis by esterification of wood |
| As dehydrating agent |
| Used as a reagent in derivative GC to form N- and O-trifluoroacetyl compounds |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Clear colourless liquid |
| Purity by GC | % w/w | Min 99.5 |
| Trifluoroacetic acid by GC | % w/w | Max 0.50 |
| Fluoride | ppm | Max 50.0 |
| Chloride | ppm | Max 50.0 |
| Sulphate | ppm | Max 500.0 |
STORAGE
Product is stored at ambient temperature.
PACKING
200 kg Composite drum
REACH STATUS
Registered
ExSyn offers TFAA on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice ! If you need any additional information or SDS, please get in touch with us.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.
Zinc Dialkyl Dithio Phosphate (ZDDP) belongs to a family of coordination compounds classified as members of transition metal dithiophosphate.
ZDDP is widely used based on a combination of different selected alcohols thus providing antiwear performance and enhanced thermal and hydrolytic stability. In combination with other additives, it is especially used for the formulation of hydraulic fluids, industrial gear oils, metalworking fluids, greases and automotive engine oils.
Dibutyl sulfide is an organosulfur. It is a clear, colorless to pale yellow liquid characterized by a strong sulfur-like odor and is primarily used as an intermediate in chemical synthesis, specialty organic manufacturing, and research applications. The compound exhibits good solvency properties and moderate thermal stability, making it useful in industrial and laboratory processes involving sulfur-containing organic compounds.
Oleylamine is a long-chain (C18) primary fatty amine derived from natural fatty acids, typically sourced from vegetable oils. It is produced from oleic acid through conversion of the carboxylic acid group (–COOH) into an amine group (–NH₂). With its optimal balance of hydrophobic chain length and reactive amine functionality it serves as a versatile and dependable building block for high-performance formulations.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.