INTRODUCTION
Tetrabutylammonium fluoride trihydrate (TBAF trihydrate) is a hygroscopic solid and is a versatile reagent in many chemical reactions. It us usually consumed in aldol-type condensation, Michael-type, and ring opening reactions.
Manufacture
TBAF trihydrate is produced by reaction of aqueous hydrogen fluoride with aqueous solution of tetrabutylammonium bromide over an Amberlite resin.
| Synonyms | Tetrabutylazanium fluoride trihydrate TBAF trihydrate |
| CAS no. | 87749-50-6 |
| EINECS no. | 207-057-2 |
| Molecular formula | C16H36NF. 3H2O |
| Molecular weight | 315.51 |
| Structure |  |
Applications
| The quaternary ammonium salt has many applications such as: |
|---|
| phase transfer catalyst |
| mild base in organic reactions |
| source of fluoride anion in organic solvents |
| reactant in synthesis of cellulose derivatives, lipophilic peptides, and in dehydrobromination reactions |
| deprotecting agent to remove silyl ether protecting group |
| It also plays an important in conversion of O-silylated enolates into carbonyl compounds in presence of DMSO. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to slight yellow solid small lumps |
| Water by KF | % | 14.00 – 19.00 |
| Assay by titration | % | Min 98.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 kg HDPE drum.
REACH Status
Not registered yet.
ExSyn offers TBAF trihydrate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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