INTRODUCTION
n-Hexyllithium in hexane solution (HxLi) is an organolithium compound primarily used in organic synthesis as a strong base, alkylating agent, and lithiation reagent. It is particularly effective in the deprotonation of weakly acidic compounds. Handling n-Hexyllithium requires strict safety precautions due to its highly reactive nature, particularly due to its sensitivity to moisture, air, and heat.
MANUFACTURE
The manufacturing process typically involves the reaction of n-hexyl chloride (C6H13Cl) with a lithium metal in a hydrocarbon solvent, like hexane.
| Synonym | n-Hexyllithium, Hexane – lithium complex; 1-Lithiohexane |
| CAS no. | 21369-64-2 |
| EINECS no. | 404-950-0 |
| Molecular formula | CH3(CH2)5Li |
| Molecular weight | 92.11 |
| Structure |  |
APPLICATIONS
Due to its high reactivity, n-Hexyllithium is crucial in synthetic chemistry and helps in creating compounds used across various industries, including pharmaceuticals, agrochemicals, materials science, and polymer production.Some of the key applications for n-Hexyllithium are as follows;
| Nucleophilic substitution (formation of C-C bonds) |
| Grignard-like reactions with carbonyl compounds |
| Formation of organometallic intermediates for further synthesis |
| Lithiation of aromatic compounds for selective substitution |
| Synthesis of conjugated dienes and other specialized organic molecules |
| Polymerization initiation for synthetic rubbers or specialty plastics |
| Preparation of lithium enolates for carbonyl chemistry |
| Synthesis of organosilicon compounds |
| Regioselective lithiation for complex molecule synthesis |
| Reduction reactions involving electrophilic groups |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Pale yellow to dark yellow color liquid |
| Solubility | – | Soluble in Hexane and Tetrahydrofuran |
| Weight /mL (at 20°C) | gm /mL | 0.700 – 0.720 |
| Molarity | M | NLT 2.55 |
| Assay (Chemical Analysis) | % | NLT 33.0 |
STORAGE
Recommended storage temperature 2° to 8°C under inert gas. Air & moisture sensitive, hence store in airtight, moisture-resistant sealed containers. Shipped in reefer container.
PACKING
500 Ltrs. UN-approved cylinder.
REACH Status
Not registered.
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