INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.
The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs. Glycidol has recently found use as a key component in a SARS COV2 testing kit.
| Synonyms: | Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane |
| CAS No.: | 556-52-5 |
| EINECS Number: | 209-128-3 |
| Molecular Formula: | C3H6O2 |
| Molecular Weight: | 74.08 |
| Structure: |  |
INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
| an epoxide building block |
| a stabilizer in PVC compounding |
| a stabilizer for natural oils and vinyl polymers |
| a dye-levelling agent and a demulsifier |
| a reactive diluent in coatings |
| an RM in syntheses of polyurethanes and hyperbranched polyglycerols |
| a gelation agent in solid propellants |
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
| Amines | > | Alkanolamines |
| Polymerization | > | Polyglecerols |
| Methylamine | > | Glycidyl Methacrylate |
| C10/C12 FAME | > | Glycidyl Fatty Acid Esters |
| C10-C18 FAME & Fatty Alcohols | > | Glycidyl Ester & Ethers as non-ionic surfactants |
MEDICAL APPLICATIONS
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.
CARDIAC AGENTS
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers, β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles
| API | THERAPEUTIC CATEGORY |
| Adrenaline | Hormone (for cardiovascular activities) |
| S-(-)-Atenolol | β-blocker |
| Bufenolol | β-blocker |
| Falintolol | β-adrenergic receptor |
| Levobunolol | β-Adrenergic blocker |
| S-(-)-Metoprolol | β-blocker |
| Naipradilol | β-blocker |
| Noradrenaline | Vasopressor |
| Oxprenolol | β-blocker |
| Propafenone | Antiarrhythmic |
| Propanolol | β-blocker |
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol
| API | THERAPEUTIC CATEGORY |
| Fexofenadine | Antihistamine |
| Guaifenesin | Expectorant |
| Indinavir Sulfate | Anti-Retroviral |
| Leinamycin | Antibiotic |
| Levodropropizine | Antitussive |
| Montelukast | Anti-asthma |
| Tenofovir | Anti-Retroviral |
BIOCHEMICAL PROBES
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.
For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | Colorless liquid |
| Identification | ||
| · IR | – | Should conform to the reference spectrum |
| H1NMR | – | Should conform to the structure |
| Assay (by GC) | % | Min 96.0 |
| Water Content (by KF) | Wt % | Max 0.5 |
STORAGE
Recommended storage temperature is 2° to 8°C.
Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.
Zinc Dialkyl Dithio Phosphate (ZDDP) belongs to a family of coordination compounds classified as members of transition metal dithiophosphate.
ZDDP is widely used based on a combination of different selected alcohols thus providing antiwear performance and enhanced thermal and hydrolytic stability. In combination with other additives, it is especially used for the formulation of hydraulic fluids, industrial gear oils, metalworking fluids, greases and automotive engine oils.
Dibutyl sulfide is an organosulfur. It is a clear, colorless to pale yellow liquid characterized by a strong sulfur-like odor and is primarily used as an intermediate in chemical synthesis, specialty organic manufacturing, and research applications. The compound exhibits good solvency properties and moderate thermal stability, making it useful in industrial and laboratory processes involving sulfur-containing organic compounds.
Oleylamine is a long-chain (C18) primary fatty amine derived from natural fatty acids, typically sourced from vegetable oils. It is produced from oleic acid through conversion of the carboxylic acid group (–COOH) into an amine group (–NH₂). With its optimal balance of hydrophobic chain length and reactive amine functionality it serves as a versatile and dependable building block for high-performance formulations.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
Pyrazinamide is a first-line antitubercular drug used in combination therapy for the treatment of tuberculosis (TB). It is a synthetic pyrazine derivative and acts as a prodrug, which is converted into its active form (pyrazinoic acid) inside Mycobacterium tuberculosis.
6-Bromopyridine-2,3-diamine is a heterocyclic organic compound belonging to the class of substituted pyridines. It is used mainly as an intermediate in pharmaceuticals and agrochemicals.
Magnesium trisilicate is an inorganic compound commonly used in pharmaceutical and gastrointestinal (GI) preparations due to its dual action. It is usually produced as a white, odorless, fine powder. It helps bind toxins or irritants in the gastrointestinal tract and occasionally used in formulations for its stabilizing properties.