INTRODUCTION
Dimethyl sulfoxide, popularly knowns by its acronym DMSO, is an organosulfur compound. It is an aprotic polar solvent, a mild oxidant, and a common ligand in co-ordination chemistry. Its versatility lies in the fact that it can dissolve polar as well as non-polar solutes and hence it is a special solvent in organic syntheses. Its utility is further due to its low cost, low toxicity, and stability.
Manufacture
It is manufactured by oxidation of dimethyl sulfide by either oxygen or nitrogen dioxide.
| Synonyms | Dimethyl sulfur oxide Methylsulfinylmethane |
| CAS no. | 67-68-5 |
| EINECS no. | 200-664-3 |
| Molecular formula | C2H6OS |
| Molecular weight | 78.13 |
| Structure |  |
Applications in Medicine
| as a solvent in in vivo and in vitro drug testing |
| used as topical analgesic |
Applications in Pharma
| DMSO is used as a solvent in production of: |
|---|
| Minoxidil, used as an antihypertensive and in dermatological preparations |
| Oxolinic acid, a quinolone antibiotic |
Applications in Intermediates
| It is a preferred solvent to manufacture intermediate products such as: |
|---|
| 1,2-Methylenedioxybenzene from resorcinol |
| 3,4-Methylenedioxyaniline |
| N-Ethyl-3,4-methylenedioxyanilline |
Generic Applications in Organic Syntheses
| DMSO-induced dehydrogenation oxidations such as Swern Oxidation and Pfitzner Moffatt Oxidation |
| Oxygen-adding oxidation such as Komblum Oxidation |
| DMSO acts as source to incorporate methyl, methylsulfonyl, and methylthio groups in substrate molecules |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Crystallization point | °C | Min 18.10 |
| Acid value | mg KOH/g | Max 0.03 |
| Transmittance at 400nm | % | Min 96.0 |
| Refractive Index at 20 °C | – | 1.4775 – 1.4790 |
| Moisture | % | Max 0.1 |
| Purity | % | Min 99.90 |
STORAGE
The product is stored at ambient temperature
PACKING
225 kg MS drum
REACH Status
Not registered yet
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