INTRODUCTION
Berberine Hydrochloride is a yellow isoquinoline alkaloid extracted from various plants such as Berberis aristata, Coptis chinensis (Chinese goldthread), and Hydrastis canadensis (goldenseal). Berberine offered by ExSyn is from Berberis aristata. It is most commonly used in its hydrochloride salt form due to its better solubility and bioavailability. It is widely known for its antimicrobial, anti-inflammatory, and metabolic regulatory properties, and has gained popularity in nutraceutical and pharmaceutical industries.
| Synonyms | Berberine chloride Benzodioxide; Natural Yellow 18 |
| CAS no. | 633-65-8 |
| EINECS no. | 211-195-9 |
| Molecular formula | C₂₀H₁₈ClNO₄ |
| Molecular weight | 371.82 |
| Structure |  |
| MANUFACTURE |
|---|
| 1. Raw Material Extraction |
| • Source Plants: Rhizomes or roots of plant Berberis. |
| • Extraction Solvent: Typically, ethanol or water is used under heat and pressure to extract the crude alkaloids. |
| 2. Alkaloid Isolation |
| • The crude extract undergoes acid-base purification to isolate berberine. |
| 3. Purification & Crystallization |
| • The berberine hydrochloride is further recrystallized to achieve pharmaceutical grade purity. |
| • Drying and milling are done to obtain the final yellow crystalline powder. |
| Key features of Berberine offered by ExSyn: |
|---|
| 100% vegan |
| Superior bioavailability & efficacy |
| Excipient free |
| Powered by OMICS technology |
| Clinically validated |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Yellow colour |
| Form | – | Granules |
| Taste | – | Characteristic Taste |
| Odour | – | Characteristic Odour |
| Ingredients | ||
| Berberine HCl (Berberis aristate) | % | NLT 85.0 |
| Aqueous Extract of Berberis aristate | % | NLT 5.0 |
| Milk Thistle Extract (Silybum marianum L.) | % | NLT 5.0 |
| Particle Size | % | NLT 80.0 pass through 30# |
| Cadmium (Cd) | ppm | NMT 1.0 |
| Arsenic (As) | ppm | NMT 1.0 |
| Mercury (Hg) | ppm | NMT 0.1 |
| Lead (Pb) | ppm | NMT 3.0 |
| Total Plate Count | cfu/ g | NMT 1000 |
| Yeast and mould | cfu/ g | NMT 100 |
| E. coli | – | Should be absent / g |
| Salmonella | – | Should be absent/ 25g |
| S. aureus | – | Should be absent/ g |
| APPLICATIONS |
|---|
| With a traditional history in Chinese and Ayurvedic medicine and growing modern scientific validation, Berberine’s use in pharmaceuticals and nutraceuticals continues to expand. |
| Pharmaceutical Applications |
| Type 2 Diabetes Management: Lowers blood glucose levels by activating AMP-activated protein kinase (AMPK). |
| Hyperlipidemia: Reduces cholesterol and triglyceride levels. |
| Anti-inflammatory and Antioxidant: Inhibits pro-inflammatory cytokines and oxidative stress. |
| Antimicrobial: Effective against bacteria (e.g., E. coli, Staphylococcus aureus), fungi, and protozoa. |
| Gastrointestinal Health: Treats diarrhea, IBS, and H. pylori infection. |
| Nutraceuticals and Dietary Supplements |
| Commonly used in capsule or tablet form as a metabolic support supplement. |
| Marketed for weight management, insulin sensitivity, and cardiovascular support. |
| Cosmetics and Personal Care |
| Sometimes included in herbal cosmetic formulations for its antibacterial and skin-soothing properties. |
| Veterinary Medicine |
| Used in herbal preparations for digestive and metabolic issues in animals. |
PACKING
2kg net weight in poly bag, placed in an export worthy HDPE drum.
STORAGE
Store at ambient temperature.
CERTIFICATIONS
GMP, HALAL, KOSHER.
ExSyn offers Berberine on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Diacetone Alcohol (DAA) is an aliphatic hydroxy ketone produced through the base-catalysed aldol addition of two acetone molecules. It contains both ketone and tertiary hydroxyl functionalities, offering excellent solvency and chemical reactivity.
As a high-boiling oxygenated solvent and valuable chemical intermediate, DAA finds broad application in paints and coatings, printing inks, adhesives, industrial cleaning, cosmetics, and textiles. It is also used as an intermediate in the production of mesityl oxide and MIBK. (4-methylpentan-2-one).
Kojic acid is a natural fungal metabolite produced through natural fermentation of carbohydrates. It works primarily as a tyrosinase inhibitor, suppressing melanin production to help reduce dark spots and even out skin tone. It also delivers antioxidant benefits, neutralizing free radicals and protecting skin cells from oxidative stress. With its naturally weak acidic profile, kojic acid is a multifunctional ingredient suited for brightening and protective skincare formulations.
(S)-Oxetan-2-yl-methanamine is a chiral oxetane-containing primary amine. The compound features a strained four-membered oxetane ring and an aminomethyl substituent, making it a valuable building block in modern medicinal chemistry. Due to its unique physicochemical properties, including increased polarity and metabolic stability compared with conventional alkyl groups, it is widely employed as an advanced pharmaceutical intermediate in drug discovery and development programs.
Guanidine carbonate is a white, crystalline, water-soluble compound with an alkaline and ionic nature. Composed of guanidinium cations and carbonate anions, it offers chemical stability, buffering capacity, and good formulation compatibility. In textile applications, it is used in formulations and fabric treatments for its thickening, softening, lubricating, anti-static, and flame-retardant properties, contributing to improved fabric finish and performance.
Tin(II) sulfide (SnS) has emerged as a safe and sustainable semiconductor owing to its non-toxicity, low cost, and natural abundance. It has attracted significant interest for solar energy conversion in thin-film photovoltaic devices because of its suitable band gap, which is approximately 1.3 eV in the orthorhombic phase and 1.5-1.7 eV in the cubic phase. In addition to photovoltaic applications, SnS is used in solid-state lubricants, near-infrared detectors, Lithium-ion batteries, and various sensing devices.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.