INTRODUCTION
Quinuclidinone Hydrochloride is a derivative of bicyclic amine quinuclidine. The hydrochloride form of quinuclidinone is the salt form, often used for its stability in different reactions. Quinuclidinone Hydrochloride is typically used as an intermediate in the synthesis of various pharmaceuticals and other chemical products.
Manufacture
The introduction of a carbonyl group (C=O) through oxidation into the quinuclidine structure yields transformation into quinuclidinone. Quinuclidinone is then converted into its Hydrochloride salt form by reacting it with Hydrochloric acid. The final compound is then purified through crystallization.
| Synonyms | 1S,2S,5R)-2-Azabicyclo[2.2.1]heptan-3-one hydrochloride; Quinuclidin-3-one Hydrochloride |
| CAS no. | 1193-65-3 |
| EINECS no. | 214-776-5 |
| Molecular formula | C7H11NO·HCl |
| Molecular weight | 161.63 |
| Structure |  |
Applications
It is a useful compound in organic chemistry. Its applications span across various fields. Below are some of its main applications;
| Pharmaceutical Intermediates |
| As a versatile building block for the preparation of drugs targeting different biological pathways. |
| Synthesis of other Nitrogen containing Heterocycles |
| In creating compounds for use in both synthetic and medicinal chemistry. |
| Synthesis of Chiral compounds |
| In development of enantioselective reactions and synthesis of optically active compounds. |
| Organometallic catalysts |
| Used in the development of ligands for metal catalysts. |
| In Neurochemical Research (Enzyme Inhibition) |
| As a modulator of acetylcholine activity and in areas of pharmacology, neuroscience, and drug development. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | White to beige colored powder |
| Solubility | – | Soluble in Methanol and water, insoluble in Ether, THF and Toluene |
| Identification (By IR) | – | Should conform to the structure |
| Loss on drying | % w/w | NMT 0.50 |
| Loss on ignition | % w/w | NMT 0.50 |
| Assay (On dried basis) | % w/w | 98.00 – 102.00 |
| Related Substances (By GC) | ||
| Purity | Area % | NLT 99.00 |
| Any unspecified Impurity | Area % | NMT 0.50 |
| Total Impurities | Area % | NMT 1.0 |
STORAGE
Store in cool, dry place out of direct sunlight in tightly sealed containers.
PACKING
25 Kg HDPE Drums
REACH Status
Not registered
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