INTRODUCTION
2-Cyclohexene-1-one is an organic intermediate used in synthesis of pharmaceuticals, agrochemicals, and fragrances. It is a ketone, or more precisely, an enone. It undergoes nucleophilic conjugate addition with organocopper reagents, Michael reactions and Robinson annulations.
Manufacture
The product is commercially manufactured by Birch reduction of phenol or anisole, alternatively by catalytic oxidation of cyclohexene.
| Synonyms | Cyclohexenone Cyclohex-2-enone |
| CAS no. | 930-68-7 |
| EINECS no. | 212-223-5 |
| Molecular formula | C6H8O |
| Molecular weight | 96.13 |
| Structure |  |
Applications in Pharma
| Cyclohexenone is a key raw material in the production of: |
|---|
| Carprofen, a nonsteroidal anti-inflammatory drug |
Applications in Agrochemicals
| It is also used to synthesize the herbicides: |
|---|
| Clethodim |
| Tralkoxydim |
Applications in Intermediates
| Following intermediates can be synthesized from cyclohexenone: |
|---|
| 3-Methylcyclohexanone |
| 2-(Hydroxymethyl)cyclohex-2-en-1-one |
Other Applications
| As fragrance ingredient with roasted savory green odor |
| In biological studies for H-tunneling in multiple hydride transfers of catalytic cycle of the enzyme – morphinone reductase |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear, colorless or slightly yellowish liquid |
| Identification by GC | – | Peak in the sample chromatogram to match with that in standard chromatogram |
| Water by KF | w/v | Max 0.5 |
| Density at 20°C | – | 0.987 – 0.997 |
| Purity by GC | % | Min 98.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
25 kg UN-approved carboy.
REACH Status
Not registered yet.
ExSyn offers 2-cyclohexene-1-one on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.