INTRODUCTION
2,4-Dichlorobenzyl alcohol (DCBA) is a member of the class of Benzyl alcohols in which the hydrogens at positions 2 and 4 are replaced by chlorines. Its effectiveness against a broad spectrum of pathogens makes it a valuable ingredient in antiseptic products.
Manufacture
Produced through a two-stage reaction, the first stage involves reacting 2,4-dichlorobenzyl chloride with a water-soluble salt of an organic acid in the presence of a phase transfer catalyst to form the 2,4-dichlorobenzyl ester of the organic acid. The second stage involves hydrolysing this ester with a strong base to yield 2,4-dichlorobenzyl alcohol (DCBA)
| Synonyms | 2,4-Dichlorophenyl)methanol; 2,4-Dichlorobenzenemethanol |
| CAS no. | 1777-82-8 |
| EINECS no. | 217-210-5 |
| Molecular formula | C7H6Cl2O |
| Molecular weight | 177.03 |
| Structure |  |
Applications
DCBA is a compound with notable biological activity, particularly in the field of antimicrobial and antiviral applications. It is often combined with other agents, such as Amylmetacresol (AMC), to enhance its antimicrobial efficacy.
Medicinal Applications
| DCBA has been incorporated into formulations such as throat lozenges and sprays, where it acts as a virucidal agent against respiratory viruses. DCBA significantly reduces throat soreness and provide pain relief. |
| Due to its broad-spectrum antimicrobial & antifungal activity it is used in several topical and cosmetic preparations. |
| DCBA is used in vaginal and rectal formulations specifically acting as virucidal in HIV and SARS-CoV infections. |
Chemical Reactions
| DCBA undergoes various chemical reactions such as oxidation, reduction and substitution to facilitate production of compounds such as; |
| – Dichlorobenzaldehyde |
| – Dichlorotoluene |
| – Various substituted benzyl alcohols depending on the nucleophile used. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Description | – | White or almost white crystalline powder |
| Solubility | – | Very slightly soluble in water, very soluble in ethanol (96%) |
| Identification (By IR) | – | The IR spectrum of the sample should be concordant with the standard spectrum of 2,4-Dichlorobenzyl alcohol |
| Melting Point | °C | About 59.0 |
| Water Content | % | NMT 0.2 |
| Sulphated Ash | % | NMT 0.1 |
| Related Substance (HPLC) | ||
| Impurity A | % | NMT 0.10 |
| Impurity B | % | NMT 0.10 |
| Impurity C | % | NMT 0.10 |
| Impurity D | % | NMT 0.10 |
| Impurity E | % | NMT 0.10 |
| Impurity F | % | NMT 0.10 |
| Impurity G | % | NMT 0.10 |
| Unspecified maximum Impurity | % | NMT 0.10 |
| Total Impurity | % | NMT 0.30 |
| Assay (By HPLC) (on anhydrous basis) | % | 98.0 – 102.0 |
| Additional Test | ||
| Impurity (By HPLC) 2,4Dichlorotoluene | % | NMT 0.10 |
| Residual Solvent Cyclohexane | ppm | NMT 3000 ppm |
| Diethylene Glycol | ppm | NMT 1000 ppm |
STORAGE & PRECAUTION
Store in cool, dry place out of direct sunlight in tightly sealed containers.
PACKING
25 Kg HDPE Drums
REGISTRATION / CERTIFICATION
c-GMP
REACH Status
Not registered
ExSyn offers 2,4 Dichlorobenzyl alcohol on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.
Indorez® Kota Resin is a modified non self-cured phenolic resin, it can increase rubber adhesion to steel, polyester, rayon, nylon, aramid and other fabric cord. It’s an adhesive agent, acts as methylene acceptor, can 100% replace resorcinol and resorcinol resins in resorcinol- formaldehyde-silica, enhance adhesion between rubber and reinforcing materials.