INTRODUCTION
Protoporphyrin IX dimethyl ester, abbreviated PPMX, is an organic moiety belonging to category porphyrins. On exposure to light, PPMX releases reactive oxygen that can be used to destroy targeted cancer cells and thus it find applications largely in medicines.
Manufacture
It is produced by esterification of protoporphyrin IX. The latter is synthesized by oxidation of protoporphyrinogen by enzyme Protoporphyrinogen Oxidase.
| Synonym | PPMX Ooporphyrin dimethyl ester |
| CAS no. | 5522-66-7 |
| EINECS no. | 226-870-3 |
| Molecular formula | C36H38N4O4 |
| Molecular weight | 590.71 |
| Structure |  |
Applications
| Derivatives |
|---|
| Porphyrin S-411 |
| Protoporphyrin A |
| Harderoporphyrin |
| Hematoporphyrin |
| Others |
|---|
| A potent photosensitizer of human naso-pharyngeal carcinoma |
| An important precursor to biologically essential prosthetic groups such as Cytochrome C |
| As a standard material in acid extraction of erythrocyte protoporphyrin |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Black powder |
| Solubility | – | Soluble in acetonitrile:THF = 1:1 |
| Identification | ||
| By TLC | – | Should be positive |
| By NMR | – | Should conform to the structure |
| Purity | % | Min 85.0 |
| LOD | % | Max 5.0 |
| Ash | % | Max 0.5 |
STORAGE
Stored at 2 – 8°C
PACKING
5 kg, 10 kg, and 10 kg drum
REACH Status
Not registered
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