INTRODUCTION
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
Manufacture
It is manufactured by difluoromethylation of 4-nitro-1H-pyrazole.
| Synonym | N-difluoromethyl-4-nitropyrazole; 1H-Pyrazole, 1-(difluoromethyl)-4-nitro- |
| CAS No. | 956477-64-8 |
| EINECS No. | 818-063-5 |
| Molecular weight | 163.08 |
| Structure |  |
Applications
| APIS : 1-(Difluoromethyl)-4-nitro-1H-pyrazole is used in synthesis of the following APIS: |
|---|
| Heterocyclic p2′ groups as factor XIa inhibitors |
| NLRP3 inflammasome modulators for the treatment of inflammatory, autoinflammatory, autoimmune and neoplastic diseases |
| an FXIa inhibitor treating thromboembolic disorders |
| Milvexian- anticoagulant |
| Intermediates |
|---|
| 1-(difluoromethyl)-1H-pyrazole-4amine |
2-(Benzylmethylamino)-1-phenylpropanone is an organics intermediate from ketone category. It is a compound with notable pharmacological potential and itself has excellent cytotoxic properties. In trade, the chemicals is referred to as AMK.
Budesonide is in a class of medications called corticosteroids. It works by decreasing inflammation (swelling) in the digestive tract of people who have Crohn’s disease or ulcerative colitis. or in the kidney of people with nephropathy.
Boron trifluoride tetrahydrofuran complex, is a colorless liquid that is commonly used as a colorless liquid that is commonly used as a Lewis acid catalyst in various organic reactions. It has a wide range of applications in the synthesis of pharmaceuticals, polymers, and other organic compounds
Nicotinamide riboside chloride (NRCL) is a unique form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, it has sparked interest in the realms of aging, metabolism, and overall cellular health.
Tetrachlorvinphos (popularly known as TCVP) is an agrochemical belonging to class of organophosphates. It is a non-systemic insecticide and acaracide having widespread uses in crop protection, public health, and animal hygiene.
Sodium Starch Glycolate (SSG) is a very fine free flowing powder that is white or off white in color and has almost no odor. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. It is a sodium salt of carboxyl ether of starch and is appreciated for its stability and binding properties.
3-([Ethyl(3-methylphenyl)amino]methyl) benzenesulfonic acid is an organic sulfonic acid, a white crystalline solid, which is widely used as a catalyst, acidifying agent, and a reagent in organic synthesis.
Sodium trifluoroacetate is a colorless organic solid belonging to category of fluoro compounds. It acts as a versatile trifluoromethylation agent in chemicals synthesis and is used to produce an array of chemical intermediates.
Iodopropynyl butylcarbamate, also known as IPBC, is an antimicrobial ingredient commonly used in cosmetics. It appears as a white, crystalline powder. It is not a paraben; it belongs to a different chemical class called carbamates. It is soluble in both water and oil-based systems. IPBC was invented in the 1970s and has a long history of effective use as an antifungal technology.