INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
| Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
| CAS no. | 108-48-5 |
| EINECS no. | 203-587-3 |
| Molecular formula | C7H9N |
| Molecular weight | 107.15 |
| Structure |  |
Applications in APIs
| The dialkylated pyridine is a KRM for production of APIs: |
|---|
| Clopidol – a veterinary medicine, used as coccidiostat. |
| Cefpiramide acid – an antibiotic |
Applications in Intermediates
| Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
|---|
| 2,6-Dimethylpiperidine |
| Dipicolinic acid |
| 2,6-Dimethylpyridine-4-amine |
| 2-Bromomethyl-6-methylpyridine |
| 2,6-Dimethylpyridine-N-oxide |
Other Applications
| As a sterically hindered mild base in organic syntheses |
| Used as food additive to impart nutty odor and flavor |
| Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Monophase clear colorless liquid with no foreign impurities |
| Solubility | – | Soluble in methanol and cold water |
| Boiling point | °C | 144-145 |
| Color | APHA | Max 20 |
| Moisture by KF | % | Max 0.2 |
| Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
| Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2,6-lutidine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals