INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
| Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
| CAS no. | 108-48-5 |
| EINECS no. | 203-587-3 |
| Molecular formula | C7H9N |
| Molecular weight | 107.15 |
| Structure |  |
Applications in APIs
| The dialkylated pyridine is a KRM for production of APIs: |
|---|
| Clopidol – a veterinary medicine, used as coccidiostat. |
| Cefpiramide acid – an antibiotic |
Applications in Intermediates
| Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
|---|
| 2,6-Dimethylpiperidine |
| Dipicolinic acid |
| 2,6-Dimethylpyridine-4-amine |
| 2-Bromomethyl-6-methylpyridine |
| 2,6-Dimethylpyridine-N-oxide |
Other Applications
| As a sterically hindered mild base in organic syntheses |
| Used as food additive to impart nutty odor and flavor |
| Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Monophase clear colorless liquid with no foreign impurities |
| Solubility | – | Soluble in methanol and cold water |
| Boiling point | °C | 144-145 |
| Color | APHA | Max 20 |
| Moisture by KF | % | Max 0.2 |
| Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
| Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2,6-lutidine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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