INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
| Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
| CAS no. | 108-48-5 |
| EINECS no. | 203-587-3 |
| Molecular formula | C7H9N |
| Molecular weight | 107.15 |
| Structure |  |
Applications in APIs
| The dialkylated pyridine is a KRM for production of APIs: |
|---|
| Clopidol – a veterinary medicine, used as coccidiostat. |
| Cefpiramide acid – an antibiotic |
Applications in Intermediates
| Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
|---|
| 2,6-Dimethylpiperidine |
| Dipicolinic acid |
| 2,6-Dimethylpyridine-4-amine |
| 2-Bromomethyl-6-methylpyridine |
| 2,6-Dimethylpyridine-N-oxide |
Other Applications
| As a sterically hindered mild base in organic syntheses |
| Used as food additive to impart nutty odor and flavor |
| Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Monophase clear colorless liquid with no foreign impurities |
| Solubility | – | Soluble in methanol and cold water |
| Boiling point | °C | 144-145 |
| Color | APHA | Max 20 |
| Moisture by KF | % | Max 0.2 |
| Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
| Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
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