INTRODUCTION
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
Manufacture
It is manufactured by difluoromethylation of 4-nitro-1H-pyrazole.
Synonym | N-difluoromethyl-4-nitropyrazole; 1H-Pyrazole, 1-(difluoromethyl)-4-nitro- |
CAS No. | 956477-64-8 |
EINECS No. | 818-063-5 |
Molecular weight | 163.08 |
Structure | ![]() |
Applications
APIS : 1-(Difluoromethyl)-4-nitro-1H-pyrazole is used in synthesis of the following APIS: |
---|
Heterocyclic p2′ groups as factor XIa inhibitors |
NLRP3 inflammasome modulators for the treatment of inflammatory, autoinflammatory, autoimmune and neoplastic diseases |
an FXIa inhibitor treating thromboembolic disorders |
Milvexian- anticoagulant |
Intermediates |
---|
1-(difluoromethyl)-1H-pyrazole-4amine |
Linoleic acid is a polyunsaturated omega-6 fatty acid. It is a colorless liquid that is virtually insoluble in water but soluble in many organic solvents. It typically occurs in nature as a triglyceride (ester of glycerin) rather than as a free fatty acid.
Ethyl Linoleate belongs to the chemical class of fatty acids, which are organic compounds with one or more long hydrocarbon chains. These molecules are characterized by having two carbons atoms with a double bond between them.
2-Picolinic acid, an organic compound, is a derivative of pyridine with a carboxylic acid substituent at the 2-position. It is a white solid that is soluble in water.
2-Phenylethylamine is a water-soluble amine with a fishy odor. It is often referred to simply as “phenethylamine”, but that can also be interpreted as 1-phenylethylamine.
4-Amino-1,2,4-triazole is an organic solid belonging to the heterocyclic category of compounds. By virtue of presence of 3 nitrogen atoms, the molecule is biologically active and thus acts as antimicrobial and antifungal agent.
4’-Cyanoacetophenone is an organic solid. It belongs to cyclic nitriles category. The presence of cyano group makes the compound reactive to form various intermediates and a few APIs. In organics syntheses, it also used as a catalyst.
3- Bromothianisole is a brominated aromatic compound with an active methyl thio group for oxidation. It has many applications in pharmaceutical and biotech industries as an intermediate for the synthesis of various organic compounds
Dichloroacetyl chloride, acronymed DCAC, is an organic solvent that belongs to the category of acid chlorides. Its uses include manufacture of APIs, agrochemicals, and a series of intermediates. It is also applied in synthesis of biologically active compounds.
1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.