INTRODUCTION

1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.

Manufacture

It is manufactured by difluoromethylation of 4-nitro-1H-pyrazole.

SynonymN-difluoromethyl-4-nitropyrazole; 1H-Pyrazole, 1-(difluoromethyl)-4-nitro-
CAS No.956477-64-8
EINECS No.818-063-5
Molecular weight163.08
Structure

Applications

APIS : 1-(Difluoromethyl)-4-nitro-1H-pyrazole is used in synthesis of the following APIS:
Heterocyclic p2′ groups as factor XIa inhibitors
NLRP3 inflammasome modulators for the treatment of inflammatory, autoinflammatory, autoimmune and neoplastic diseases
an FXIa inhibitor treating thromboembolic disorders
Milvexian- anticoagulant
Intermediates
1-(difluoromethyl)-1H-pyrazole-4amine
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