INTRODUCTION

Valeryl chloride is an organic liquid belonging  to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.

Manufacture

Valeryl chloride is produced by chlorination of valeric acid using either phosphorus trichloride or thionyl chloride.

SynonymPentanoyl chloride
Valeroyl chloride
CAS no.638-29-9
EINECS no.211-330-1
Molecular formulaC5H9ClO
Molecular weight120.58
Structure

Applications

APIS– Valeryl chloride is a KRM in production of:
Irbesartan, an angiotensin
Valsartan, also an angiotensin
Dronedarone, for indication of cardiac arrhythmias
Diflucortolone Valerate, an anti-inflammatory drug
Pyrovalerone, a psychoactive drug
Intermediates– It also finds uses in synthesis of intermediates such as:
2-Bromo-1-phenyl-pentan-1-one
Valeric anhydride
2-Chloropentanoyl chloride
1-Octen-4-one
Phenyl valerate
Agrochemicals
Hexaconazole, a fungicide
Others
Liquid crystal synthesis
Preparation of potent inhibitor of secretory Phospholipase A2
Enantioselective synthesis of propyl isopropyl acetamide (PID)
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