INTRODUCTION
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
Manufacture
Valeryl chloride is produced by chlorination of valeric acid using either phosphorus trichloride or thionyl chloride.
| Synonym | Pentanoyl chloride Valeroyl chloride |
| CAS no. | 638-29-9 |
| EINECS no. | 211-330-1 |
| Molecular formula | C5H9ClO |
| Molecular weight | 120.58 |
| Structure |  |
Applications
| APIS– Valeryl chloride is a KRM in production of: |
|---|
| Irbesartan, an angiotensin |
| Valsartan, also an angiotensin |
| Dronedarone, for indication of cardiac arrhythmias |
| Diflucortolone Valerate, an anti-inflammatory drug |
| Pyrovalerone, a psychoactive drug |
| Intermediates– It also finds uses in synthesis of intermediates such as: |
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| 2-Bromo-1-phenyl-pentan-1-one |
| Valeric anhydride |
| 2-Chloropentanoyl chloride |
| 1-Octen-4-one |
| Phenyl valerate |
| Agrochemicals |
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| Hexaconazole, a fungicide |
| Others |
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| Liquid crystal synthesis |
| Preparation of potent inhibitor of secretory Phospholipase A2 |
| Enantioselective synthesis of propyl isopropyl acetamide (PID) |
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