INTRODUCTION
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
Manufacture
Valeryl chloride is produced by chlorination of valeric acid using either phosphorus trichloride or thionyl chloride.
| Synonym | Pentanoyl chloride Valeroyl chloride |
| CAS no. | 638-29-9 |
| EINECS no. | 211-330-1 |
| Molecular formula | C5H9ClO |
| Molecular weight | 120.58 |
| Structure |  |
Applications
| APIS– Valeryl chloride is a KRM in production of: |
|---|
| Irbesartan, an angiotensin |
| Valsartan, also an angiotensin |
| Dronedarone, for indication of cardiac arrhythmias |
| Diflucortolone Valerate, an anti-inflammatory drug |
| Pyrovalerone, a psychoactive drug |
| Intermediates– It also finds uses in synthesis of intermediates such as: |
|---|
| 2-Bromo-1-phenyl-pentan-1-one |
| Valeric anhydride |
| 2-Chloropentanoyl chloride |
| 1-Octen-4-one |
| Phenyl valerate |
| Agrochemicals |
|---|
| Hexaconazole, a fungicide |
| Others |
|---|
| Liquid crystal synthesis |
| Preparation of potent inhibitor of secretory Phospholipase A2 |
| Enantioselective synthesis of propyl isopropyl acetamide (PID) |
Nicotinamide riboside chloride (NRCL) is a unique form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, it has sparked interest in the realms of aging, metabolism, and overall cellular health.
Tetrachlorvinphos (popularly known as TCVP) is an agrochemical belonging to class of organophosphates. It is a non-systemic insecticide and acaracide having widespread uses in crop protection, public health, and animal hygiene.
Sodium Starch Glycolate (SSG) is a very fine free flowing powder that is white or off white in color and has almost no odor. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. It is a sodium salt of carboxyl ether of starch and is appreciated for its stability and binding properties.
3-([Ethyl(3-methylphenyl)amino]methyl) benzenesulfonic acid is an organic sulfonic acid, a white crystalline solid, which is widely used as a catalyst, acidifying agent, and a reagent in organic synthesis.
Sodium trifluoroacetate is a colorless organic solid belonging to category of fluoro compounds. It acts as a versatile trifluoromethylation agent in chemicals synthesis and is used to produce an array of chemical intermediates.
Iodopropynyl butylcarbamate, also known as IPBC, is an antimicrobial ingredient commonly used in cosmetics. It appears as a white, crystalline powder. It is not a paraben; it belongs to a different chemical class called carbamates. It is soluble in both water and oil-based systems. IPBC was invented in the 1970s and has a long history of effective use as an antifungal technology.
Stevia extract with Rebaudioside A (98%) is one of the sweet tasting steviol glycoside, extracted and purified from Stevia rebaudiana (Bertoni) – a small perennial shrub also known as “Honey leaf”. The leaves of S. rebaudiana contain more than 30 different steviol glycosides, among which stevioside and rebaudioside A are present in the highest levels. It is non-nutritive and tastes approximately 200-300 times sweeter than sucrose.
Protoporphyrin IX dimethyl ester, abbreviated PPMX, is an organic moiety belonging to category porphyrins. On exposure to light, PPMX releases reactive oxygen that can be used to destroy targeted cancer cells and thus it find applications largely in medicines.
Cetylpyridinium chloride is the chloride salt form of cetylpyridinium, a quaternary ammonium with broad-spectrum antimicrobial activity. Upon topical administration, cetylpyridinium chloride is positively charged and reacts with the negatively charged microbial cell surfaces, thereby destroying the integrity of the cell membrane.