Sodium tert-butoxide is a stronger base (than primary and secondary alcoholates) and a non-nucleophilic base. It is flammable and moisture sensitive. It forms clusters in the solid state, both hexamers and nonamers, It is similar in reactivity to the more common potassium tert-butoxide.

The compound is produced by treating tert-butyl alcohol with sodium hydride.

SynonymsSodium t-butoxide
Sodium tert.-butylate
CAS no.865-48-5
EINECS no.212-741-9
Molecular formulaC₄H₉ONa
Molecular weight96.10
Sodium tert-butoxide is used as:

A promoter for the synthesis of biaryls by C-H bond arylation of aromatic compounds with haloarenes.

A base in palladium catalyzed amination reactions.

A base in the synthesis of aryl tert-butyl ethers from unactivated aryl halides in presence of palladium catalyst.

In the desulfonylation of N-indoles and N-azaindoles.

As a base in the synthesis of sodium acrylates from olefins and CO2.
It acts as a catalyst in polymerization and isomerization reactions.
In organic synthesis, it serves as an intermediate in various reactions like condensation, rearrangement and ring-opening.
Further, it finds use in agrochemicals, pharmaceuticals, colorants, aroma chemicals, detergents and biodiesel.


AppearanceWhite to off-white powder
Total alkalinity (Calculated as NTB)% w/wMin 99.0
NaOH + Na2CO3
(Calculated as NaOH)
% w/wMax 1.0
Sodium-tert-butoxide (NTB)% w/wMin 97.0

UN approved packing
– 100 gm to 500 gm for sample
– 1 kg
– 5 kg
– 10 kg (2 x 5 kg)
– 50 kg (10 x 5 kg)
– Any other packing as per customer request

NTB should be stored in a cool place away from heat, sparks and flame.

REACH Status
NTB offered by ExSyn is registered under EU REACH regulations.

No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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