INTRODUCTION

Racemic quinuclidinol is an off-white solid that possesses medicinal properties. It is an alkaloid abundant in nature, especially in Erythroxylum coca.  Synthetically manufactured product finds usage in APIs, intermediates, and medicinal chemistry.

Manufacture
It is commercially manufactured by optical resolution of 3-quinuclidinol, the by-product being (R)-(-)-3-quinuclidinol.

SynonymS-3-Quinuclidinol
(S)-3-Hydroxyquinuclidine
(3S)-1-Azabicyclo[2.2.2]octan-3-ol
CAS no.34583-34-1
EINECS no.681-383-7
Molecular formulaC7H13NO
Molecular weight127.18
Structure

Applications

Quinuclidinol is used in the manufacture of following APIs
Solifenacin HCl, treats urinary inconsistence
Clidinium, an anticholinergic drug
Umeclidinium, to treat shortness of breath
Penehyclidine HCl, a selective anticholinergic
Solifenacin succinate, an antimuscarinic agent
Intermediates
(S)-(-)-3-Aminoquinuclidine HCl
Others
As reagent in chemoselective alpha-iodination of acrylic esters and for cleavage of beta-keto esters
As synthon for preparation of cholinergic receptor ligands and anesthetics

SPECIFICATIONS

TestUnitSpecification
AppearanceCream coloured to off-white solid
Melting range°C210.0 – 220.0
LOD at 50 °C%Max 1.0
Purity by GC%Min 95.0
Purity by Chiral HPLC%Min 99.0

STORAGE
Stored at ambient temperature.

PACKING
25 kg UN approved HDPE drum.

REACH Status
Not registered yet.

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