INTRODUCTION
Racemic quinuclidinol is an off-white solid that possesses medicinal properties. It is an alkaloid abundant in nature, especially in Erythroxylum coca. Synthetically manufactured product finds usage in APIs, intermediates, and medicinal chemistry.
Manufacture
It is commercially manufactured by optical resolution of 3-quinuclidinol, the by-product being (R)-(-)-3-quinuclidinol.
| Synonym | S-3-Quinuclidinol (S)-3-Hydroxyquinuclidine (3S)-1-Azabicyclo[2.2.2]octan-3-ol |
| CAS no. | 34583-34-1 |
| EINECS no. | 681-383-7 |
| Molecular formula | C7H13NO |
| Molecular weight | 127.18 |
| Structure |  |
Applications
| Quinuclidinol is used in the manufacture of following APIs |
|---|
| Solifenacin HCl, treats urinary inconsistence |
| Clidinium, an anticholinergic drug |
| Umeclidinium, to treat shortness of breath |
| Penehyclidine HCl, a selective anticholinergic |
| Solifenacin succinate, an antimuscarinic agent |
| Intermediates |
|---|
| (S)-(-)-3-Aminoquinuclidine HCl |
| Others |
|---|
| As reagent in chemoselective alpha-iodination of acrylic esters and for cleavage of beta-keto esters |
| As synthon for preparation of cholinergic receptor ligands and anesthetics |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Cream coloured to off-white solid |
| Melting range | °C | 210.0 – 220.0 |
| LOD at 50 °C | % | Max 1.0 |
| Purity by GC | % | Min 95.0 |
| Purity by Chiral HPLC | % | Min 99.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 kg UN approved HDPE drum.
REACH Status
Not registered yet.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Sodium Decane-1-Sulfonate is a surfactant with a long hydrophobic tail and hydrophilic sulfonate group, used to reduce surface tension and stabilize emulsions. It is commonly used in detergents, personal care products, and chemical formulations to enhance solubility and improve performance.
Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. It is a multifunctional Oil-in- Water Emulsifier that is a very versatile and multifunctional non-ionic surfactant used as fragrance builder and fragrance solubilizer,emulsifier in cosmetics and as pharmaceutical aid.
Trifluoroacetic anhydride is an organic liquid that belongs to the category of fluorochemicals. It is an anhydride of trifluoroacetic acid and has uses in APIs, intermediates, and agrochemicals. It is also a building block to introduce trifluoroacetyl group in organic moieties.
Benzene-d6 is a deuterated form of benzene, where hydrogen atoms are replaced by deuterium, making it ideal for use as a solvent in NMR spectroscopy. It is widely employed in chemical, pharmaceutical, and environmental research for isotopic labeling and reaction mechanism studies.
Pyridinium tribromide, an organic solid from the category of heterocyclic halides, is a highly efficient and selective bromination agent in organic syntheses. It is also used in production of APIs and intermediates.
Pyrophosphoryl Tetrachloride is a colorless fuming corrosive liquid .It consists of a pyrophosphate (a molecule with a P-O-P bond) group, where one phosphorus atom is bonded to four chlorine atoms and the other is bonded to three chlorine atoms.
It is a reactive chemical compound and should be handled with care. Commonly used in the synthesis of other phosphorus-containing compounds and as a chlorinating agent in organic chemistry
Trifluoroacetic acid (TFA) is widely used in organic synthesis as a solvent, catalyst, and reagent, owing to its reactivity and stability under adverse conditions. It is considered as one of the most economical fluorinated building blocks.
Acryloyl chloride is an organic liquid from the class of acid chlorides. It is a toxic and lachrymatic chemical that has a variety of applications in APIs, intermediates and polymers.
Triton X-100 is a widely used non-ionic surfactant and emulsifier that effectively solubilizes powders and proteins. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.