INTRODUCTION

Racemic quinuclidinol is an off-white solid that possesses medicinal properties. It is an alkaloid abundant in nature, especially in Erythroxylum coca.  Synthetically manufactured product finds usage in APIs, intermediates, and medicinal chemistry.

Manufacture
It is commercially manufactured by optical resolution of 3-quinuclidinol, the by-product being (R)-(-)-3-quinuclidinol.

SynonymS-3-Quinuclidinol
(S)-3-Hydroxyquinuclidine
(3S)-1-Azabicyclo[2.2.2]octan-3-ol
CAS no.34583-34-1
EINECS no.681-383-7
Molecular formulaC7H13NO
Molecular weight127.18
Structure

Applications

Quinuclidinol is used in the manufacture of following APIs
Solifenacin HCl, treats urinary inconsistence
Clidinium, an anticholinergic drug
Umeclidinium, to treat shortness of breath
Penehyclidine HCl, a selective anticholinergic
Solifenacin succinate, an antimuscarinic agent
Intermediates
(S)-(-)-3-Aminoquinuclidine HCl
Others
As reagent in chemoselective alpha-iodination of acrylic esters and for cleavage of beta-keto esters
As synthon for preparation of cholinergic receptor ligands and anesthetics

SPECIFICATIONS

TestUnitSpecification
AppearanceCream coloured to off-white solid
Melting range°C210.0 – 220.0
LOD at 50 °C%Max 1.0
Purity by GC%Min 95.0
Purity by Chiral HPLC%Min 99.0

STORAGE
Stored at ambient temperature.

PACKING
25 kg UN approved HDPE drum.

REACH Status
Not registered yet.

No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

More Products
In Focus: Cetylpyridinium chloride monohydrate
Products in focus · 28/02/2024

Cetylpyridinium chloride is the chloride salt form of cetylpyridinium, a quaternary ammonium with broad-spectrum antimicrobial activity. Upon topical administration, cetylpyridinium chloride is positively charged and reacts with the negatively charged microbial cell surfaces, thereby destroying the integrity of the cell membrane.

READ MORE
In Focus:N2-isobutyryl-2′-OMe-guanosine
Products in focus · 20/02/2024

N2-Isobutyryl-2′-O-methyl-guanosine (IBG) is a modified nucleoside that has gained significant attention in recent years due to its potential therapeutic and industrial applications. IBG is a derivative of guanosine, a nucleoside that is a building block of RNA and DNA.

READ MORE
In Focus: Trimethylaluminium, 2M in Toluene
Products in focus · 13/02/2024

Trimethylaluminium belongs to class of organometallics. It is a highly reactive chemical and its solution in toluene is normally used to facilitate workability. Its general applications are in cross coupling and carboalumination reactions.

READ MORE
In Focus : Octenidine Dihydrochloride
Products in focus · 06/02/2024

Octenidine dihydrochloride is a cationic surfactant, with a gemini-surfactant structure. Since 1987, it has been used primarily in Europe as an antiseptic prior to medical procedures, including on neonates. It is safe to handle and chemically stable.

READ MORE
In Focus : Allyl Glycidyl Ether
Products in focus · 30/01/2024

Allyl Glycidyl Ether (AGE) is a multifunctional organic intermediate made from epichlorohydrin and allyl chloride and is featured by high functionality and low chlorine content. Since it has an epoxy group and an allyl group, AGE reacts with a wide range of compounds.

READ MORE
In Focus : L-Fucose
Products in focus · 23/01/2024

L-Fucose is a colourless solid that belongs to class of deoxy sugars and is considered as one of the essential sugars for smooth functioning of the body. It occurs naturally in brown algal polysaccharide fucoidan and gums.

READ MORE
In Focus : Liposomal Iron
Products in focus · 16/01/2024

Liposomal iron involves encapsulating iron molecules within lipid bilayers. This encapsulation protects the iron from interactions with other compounds, enhance its stability, improve its bioavailability and low incidence of side effects.

READ MORE
In Focus – Polyethylene Glycol (PEG) – Pharma Grade
Products in focus · 09/01/2024

Polyethylene glycols (PEG), also known as macrogols, are liquid or solid polymers of the general formula H(OCH2CH2)n OH, where n is greater or equal to four.

READ MORE
In Focus : Arachidonic Acid
Products in focus · 19/12/2023

Arachidonic acid is an omega-6 fatty acid. The compound is abundant in liver, brain, and depot fats of animals. It is also found in chicken, egg, fish, and human mother milk.

READ MORE