INTRODUCTION
Propionic Anhydride is a colorless liquid having a pungent odor and high boiling point. It is miscible with most organic solvents. It is soluble in both water and alcohol.
It is a widely used reagent in organic synthesis as well as for producing specialty derivatives of cellulose.
Manufacture
Industrial route to propionic anhydride involves thermal dehydration, driving off the water by distillation.
Propionic anhydride has also been prepared by dehydration of propionic acid using ketene.
| Synonyms | Propanoic anhydride Methylacetic anhydride |
| CAS no. | 123-62-6 |
| EINECS no. | 204-638-2 |
| Molecular formula | C6H10O3 |
| Molecular weight | 130.14 |
| Structure |  |
Applications
| Pharmaceuticals | It is used in the production of Fentanyl (pain management) & Deprodone propionate (anti-inflammatory). |
| Agrochemicals | It is being used as an important building block for Clethodim (herbicide). |
| Intermediates | Propiophenone, 6-methylcoumarin are some of the intermediates that can be synthesized from Propionic anhydride. |
| Other | It is used in polymers and reactive dyes. Also, used as acylating agent for cellulose acetate propionate. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless liquid with a characteristic odor |
| Identification (by GC) | – | The retention time of the principle peak should correspond to the one obtained with the standard |
| Density at 20°C | g/ml | 1.005 – 1.015 |
| Purity (by GC) | % | Min 99.0 |
STORAGE
Store in original container at room temperature. Use nitrogen blanket, when part load removed.
PACKING
200 kg UN approved HDPE drum
REACH Status
Not registered yet.
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