Phenyl chloroformate (PCF), an organic, volatile liquid, is an important reactant in chemical syntheses. It forms a series of intermediates that are further consumed to produce APIs, agrochemicals, and polymers.  The chloroformate is also employed in proteomic research and itself is a phosgenation reagent.


Phenyl chloroformate is manufactured by phosgenation of phenol. Less hazardous synthesis route involves phenol, MDC, and triphosgene.

SynonymsChloroformic acid phenyl ester
Phenyl chloridocarbonate
CAS no.1885-14-9
EINECS no.217-547-8
Molecular formulaC7H5ClO2
Molecular weight156.6

Applications in APIs

Chloroformic acid phenyl ester is a key intermediate in the production of APIs:

APITherapeutic Category
SorafenibKinase inhibitor
LeuprorelinProstate cancer treatment
Xamoterol hemifumerateCardiac stimulant

Applications in Intermediate Syntheses

PCF forms an important raw material for the following intermediate compounds:

Ethyl phenyl carbonate
Phenyl carbamate
Benzyl phenyl carbonate

Applications in Agrochemicals

PCF is used to manufacture sulphonyl urea herbicides such as Amidosulfuron and Flazasulfuron.

Other Applications

The chloroformate exhibits further versatility as:

Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis
Dehydrating agent to convert amides into nitriles


AppearanceColorless to yellow liquid
Purity%Min 99.0
Organic solvent%Max 1.0
Phenol%Max 0.1
Diphenyl carbonate%Max 1.0
Hydrolysable chlorineppmMax 3000
Moisture%Max 0.3

The product is stored at ambient temperature.

– 225 kg UN-approved MS Composite drum
– ISO-tank

REACH Status
Not registered yet.

ExSyn offers PCF on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.

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