Phenyl chloroformate (PCF), an organic, volatile liquid, is an important reactant in chemical syntheses. It forms a series of intermediates that are further consumed to produce APIs, agrochemicals, and polymers. The chloroformate is also employed in proteomic research and itself is a phosgenation reagent.
Phenyl chloroformate is manufactured by phosgenation of phenol. Less hazardous synthesis route involves phenol, MDC, and triphosgene.
|Synonyms||Chloroformic acid phenyl ester|
Applications in APIs
Chloroformic acid phenyl ester is a key intermediate in the production of APIs:
|Leuprorelin||Prostate cancer treatment|
|Xamoterol hemifumerate||Cardiac stimulant|
Applications in Intermediate Syntheses
PCF forms an important raw material for the following intermediate compounds:
|Ethyl phenyl carbonate|
|Benzyl phenyl carbonate|
Applications in Agrochemicals
PCF is used to manufacture sulphonyl urea herbicides such as Amidosulfuron and Flazasulfuron.
The chloroformate exhibits further versatility as:
|Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis|
|Dehydrating agent to convert amides into nitriles|
|Appearance||–||Colorless to yellow liquid|
|Organic solvent||%||Max 1.0|
|Diphenyl carbonate||%||Max 1.0|
|Hydrolysable chlorine||ppm||Max 3000|
The product is stored at ambient temperature.
– 225 kg UN-approved MS Composite drum
Not registered yet.
ExSyn offers PCF on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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