INTRODUCTION
Phenyl chloroformate (PCF), an organic, volatile liquid, is an important reactant in chemical syntheses. It forms a series of intermediates that are further consumed to produce APIs, agrochemicals, and polymers. The chloroformate is also employed in proteomic research and itself is a phosgenation reagent.
Manufacture
Phenyl chloroformate is manufactured by phosgenation of phenol. Less hazardous synthesis route involves phenol, MDC, and triphosgene.
| Synonyms | Chloroformic acid phenyl ester Phenyl chloridocarbonate |
| CAS no. | 1885-14-9 |
| EINECS no. | 217-547-8 |
| Molecular formula | C7H5ClO2 |
| Molecular weight | 156.6 |
| Structure |  |
Applications in APIs
Chloroformic acid phenyl ester is a key intermediate in the production of APIs:
| API | Therapeutic Category |
|---|---|
| Rilmenidine | Anti-hypertensive |
| Sorafenib | Kinase inhibitor |
| Droxicam | Anti-inflammatory |
| Camazepam | Depressant |
| Leuprorelin | Prostate cancer treatment |
| Xamoterol hemifumerate | Cardiac stimulant |
Applications in Intermediate Syntheses
PCF forms an important raw material for the following intermediate compounds:
| 1,4-Beneznedimethanol |
| Ethyl phenyl carbonate |
| Piperidine-2-ethanol |
| Cbz-D-phenylalaninol |
| 4,6-dimethoxy-2(phenoxycarbonyl)aminopyrimidine |
| Phenyl carbamate |
| Benzyl phenyl carbonate |
Applications in Agrochemicals
PCF is used to manufacture sulphonyl urea herbicides such as Amidosulfuron and Flazasulfuron.
Other Applications
The chloroformate exhibits further versatility as:
| Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis |
| Dehydrating agent to convert amides into nitriles |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Colorless to yellow liquid |
| Purity | % | Min 99.0 |
| Organic solvent | % | Max 1.0 |
| Phenol | % | Max 0.1 |
| Diphenyl carbonate | % | Max 1.0 |
| Hydrolysable chlorine | ppm | Max 3000 |
| Moisture | % | Max 0.3 |
STORAGE
The product is stored at ambient temperature.
PACKING
– 225 kg UN-approved MS Composite drum
– ISO-tank
REACH Status
Not registered yet.
ExSyn offers PCF on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.
The product, acronymed ETD, is an organic compound with a fused bicyclic ring system and an ethylidene group. The structure renders the chemical special properties leading to its applications in diverse fields.
Sodium perchlorate monohydrate is the inorganic compound with the chemical formula NaClO4•H2O. It is the common existence form of sodium perchlorate, which can gradually absorb water in the air to form the monohydrate. Sodium perchlorate monohydrate is white rhombic crystal which is highly soluble in water and in alcohol. Its capacity to undergo redox reactions, liberating oxygen atoms, has been harnessed in the preparation of specialty chemicals, including pharmaceutical intermediates and fine chemicals.
Triphenylphosphine is a common organophosphorus compound that is frequently abbreviated as PPh3 or Ph3P. It is widely used in organic and organometallic compound synthesis because it is an effective reducing agent as well as a neutral ligand. At room temperature, PPh3 crystals are relatively air-stable and colourless.
Potassium chlorate holds significant importance across various industries due to its diverse applications. This white crystalline compound has been utilized for centuries as an essential ingredient in the production of matches, fireworks, and explosives, owing to its ability to release oxygen upon decomposition.
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It is an organic heterotetracyclic compound that has a Furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
Octadecylphosphonic acid (ODPA), a versatile chemical compound, serves as a surfactant and dispersant in applications spanning coatings, lubricants, and corrosion inhibition. With its hydrophobic octadecyl chain linked to a phosphonic acid group, it excels in surface modification, boosting adhesion in metal surfaces.
2-(Benzylmethylamino)-1-phenylpropanone is an organics intermediate from ketone category. It is a compound with notable pharmacological potential and itself has excellent cytotoxic properties. In trade, the chemicals is referred to as AMK.
Budesonide is in a class of medications called corticosteroids. It works by decreasing inflammation (swelling) in the digestive tract of people who have Crohn’s disease or ulcerative colitis. or in the kidney of people with nephropathy.