Permethrin is an insecticide in the pyrethroid family. Pyrethroids are synthetic chemicals that act like natural extracts from the chrysanthemum flower.
Permethrin is produced by condensation of 3-phenoxybenzyl alcohol with (1RS)-cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid.
|3- (2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (3 –phenoxyphenyl)-methyl ester; 3-phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
Permethrin is used in agricultural, textile, food and pharma industries. Some of the key applications where it is used are:
|to protect crops & to kill livestock parasites
|on structures and buildings, including livestock housing and food-handling establishments. Permethrin can also be used in numerous residential sites, both indoor and outdoor and on pets
|to prevent insect attack on woollen products
|in aircraft disinfection
|as a personal protective measure, permethrin is applied to clothing. It is a cloth impregnant, notably in mosquito nets and field wear.
|while permethrin may be marketed as an insect repellent, it doesn’t prevent insects from landing. Instead, it works by incapacitating or killing insects before they can bite.
|in pet flea preventive collars or treatment (safe for use on dogs but not cats)
|in timber treatment
|available for topical use as a cream or lotion
|used for the treatment and prevention in exposed individuals of head lice
|used as a medication in the treatment of scabies in humans and animals
SPECIFICATIONS – EP
|Colorless or slightly brownish viscous liquid, semi solid or crystalline solid.
|Practically insoluble in water, very soluble in heptane, freely soluble in anhydrous ethanol, sparingly soluble in ethylene glycol.
– by IR
– by HPLC
IR Spectrum exhibits maxima which are only at the same wave number as those in “Reference Spectrum of Permethrin Reference Standard“
The 2 Principal peaks in the chromatogram obtained with the test solution are similar in retention time and in cis/trans ratio to the 2 principal peaks in the chromatogram obtained with the reference solution
|Water (by KF)
|Related Substances (by GC)
– Impurity B
– Impurity C
– Impurity G
– Unspecified Impurities
– Total Impurity
|Assay (on anhydrous basis)
|98.0 – 102.0
|23.0 – 27.0
|73.0 – 77.0
*Benzene is not used in process, but tested due to the use of Toluene
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