N-Iodosuccinimide (NIS) is a heterocyclic organic compound. It is iodination and mild oxidation agent. In iodination reactions, NIS is preferred over molecular iodine for the ease of handling. The halogenated succinimide has various applications in organics chemistry and medical sciences.
It is manufactured by iodination of succinimide in aqueous caustic soda solution.
|NIS is used as reagent in the following organics chemicals reactions:|
|Iodination of alkenes to form iodoalkanes|
|Conversion of thioglyconate to 1-hydroxy glyconate|
|Preparation of vinyl sulphones from olefins|
|Oxidative cleavage of vicinal, mono-protected diols|
|Oxidation of tosylhydrazine|
|Iodination of C-5 positions of dialkoxypyrimidines and uracils|
|Preparation of 4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine|
|Oxidative conversion of sulphur compounds|
|N-iodosuccinimide also finds use in medical sciences. It is used in study of metabolism of drugs and other compounds in cell culture.|
|Appearance||–||Off-white to slightly tan crystalline powder|
|Melting range||°C||198.0 – 206.0|
|LOD at 60 °C, 3 hours||%||Max 0.1|
|NBS content||%||Max 0.3|
Stored at ambient temperature
25 kg UN-approved HDPE drum
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