INTRODUCTION

N-Iodosuccinimide (NIS) is a heterocyclic organic compound.  It is iodination and mild oxidation agent. In iodination reactions, NIS is preferred over molecular iodine for the ease of handling. The halogenated succinimide has various applications in organics chemistry and medical sciences.

Manufacture
It is manufactured by iodination of succinimide in aqueous caustic soda solution.

SynonymNIS
Succiniodimide
1-Iodo-2,5-pyrrolidinedione
CAS no.516-12-1
EINECS no.208-221-6
Molecular formulaC4H4INO2
Molecular weight224.98
Structure

Applications

NIS is used as reagent in the following organics chemicals reactions:
Iodination of alkenes to form iodoalkanes
Conversion of thioglyconate to 1-hydroxy glyconate
Preparation of vinyl sulphones from olefins
Oxidative cleavage of vicinal, mono-protected diols
Oxidation of tosylhydrazine
Iodination of C-5 positions of dialkoxypyrimidines and uracils
Preparation of 4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
Oxidative conversion of sulphur compounds
N-iodosuccinimide also finds use in medical sciences. It is used in study of metabolism of drugs and other compounds in cell culture.

SPECIFICATIONS

TestUnitSpecification
AppearanceOff-white to slightly tan crystalline powder
Melting range°C198.0 – 206.0
LOD at 60 °C, 3 hours%Max 0.1
NBS content%Max 0.3
Assay%Min 99.5

STORAGE
Stored at ambient temperature

PACKING
25 kg UN-approved HDPE drum

REACH Status
Not registered yet

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