INTRODUCTION
N-Iodosuccinimide (NIS) is a heterocyclic organic compound. It is iodination and mild oxidation agent. In iodination reactions, NIS is preferred over molecular iodine for the ease of handling. The halogenated succinimide has various applications in organics chemistry and medical sciences.
Manufacture
It is manufactured by iodination of succinimide in aqueous caustic soda solution.
| Synonym | NIS Succiniodimide 1-Iodo-2,5-pyrrolidinedione |
| CAS no. | 516-12-1 |
| EINECS no. | 208-221-6 |
| Molecular formula | C4H4INO2 |
| Molecular weight | 224.98 |
| Structure |  |
Applications
| NIS is used as reagent in the following organics chemicals reactions: |
|---|
| Iodination of alkenes to form iodoalkanes |
| Conversion of thioglyconate to 1-hydroxy glyconate |
| Preparation of vinyl sulphones from olefins |
| Oxidative cleavage of vicinal, mono-protected diols |
| Oxidation of tosylhydrazine |
| Iodination of C-5 positions of dialkoxypyrimidines and uracils |
| Preparation of 4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine |
| Oxidative conversion of sulphur compounds |
| N-iodosuccinimide also finds use in medical sciences. It is used in study of metabolism of drugs and other compounds in cell culture. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to slightly tan crystalline powder |
| Melting range | °C | 198.0 – 206.0 |
| LOD at 60 °C, 3 hours | % | Max 0.1 |
| NBS content | % | Max 0.3 |
| Assay | % | Min 99.5 |
STORAGE
Stored at ambient temperature
PACKING
25 kg UN-approved HDPE drum
REACH Status
Not registered yet
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
5-Methyl-3-vinyl-2-oxazolidinone (V-MOX) is a highly reactive monomer valued for its low viscosity, mild odor, and excellent reactivity. It is widely used as a reactive diluent in UV-curable inks and coatings, where it enhances adhesion, produces brighter colors, and improves safety compared to conventional diluents. In addition, V-MOX serves as a key building block in the synthesis of kinetic hydrate inhibitor (KHI) polymers, which are applied in oil and gas production to prevent hydrate blockages in pipelines.
Zinc ricinoleate is the zinc salt of ricinoleic acid, a hydroxylated fatty acid derived mainly from castor oil (Ricinus communis). It appears as a white to slightly yellowish powder, waxy solid, or paste, depending on formulation. Its most valuable property is its ability to trap and absorb odor molecules such as amines, sulfides, and short-chain fatty acids, making it an essential ingredient in deodorant and odor-control products.
2-(tert-Butyl amino)ethyl methacrylate (TBAEMA) is a functional methacrylate monomer that contains a secondary amine group and a hydrophobic tert-butyl moiety, giving it excellent versatility in pH-responsive and adhesion-enhancing polymer systems.
It is valued in printing ink formulations for its ability to enhance adhesion, flexibility, and surface interaction.
Commonly known as potassium bis(fluorosulfonyl)imide (KFSI), the compound has a three-carbon backbone bearing six fluorine atoms and two sulfonimide (-SO₂F) groups. The molecule’s architecture lends it both high chemical stability and useful reactivity. Because of its excellent ionic conductivity and thermal / electrochemical stability, it finds use in advanced electrolyte formulations—for example in lithium-ion and next-generation batteries, in ionic liquids, and in other electrochemical systems.
Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.
1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.
Atropine sulfate monohydrate is a chemical compound, specifically a salt of atropine and sulfuric acid, with one water molecule (monohydrate) attached. It is commonly used as a medication and in research due to its anticholinergic properties, meaning it blocks the effects of acetylcholine at muscarinic receptors.
4-Aminobenzoic acid, commonly abbreviated as PABA, is an aromatic amine and carboxylic acid compound. It consists of a benzene ring substituted with an amino group (–NH₂) in the para position to a carboxylic acid group (–COOH).
2-Amino-5-Nitrophenol (5-NAP) is an organic compound with the molecular formula C₆H₆N₂O₃. It is a substituted phenol with both an amino group (-NH₂) and a nitro group (-NO₂) attached to a benzene ring, along with a hydroxyl group (-OH).