INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.

The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs. Glycidol has recently found use as a key component  in a SARS COV2 testing kit.

Synonyms: Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane
CAS No.:556-52-5
EINECS Number: 209-128-3
Molecular Formula:C3H6O2
Molecular Weight:74.08
Structure:

INDUSTRIAL APPLICATIONS
The racemic product as such acts as:

an epoxide building block
a stabilizer in PVC compounding
a stabilizer for natural oils and vinyl polymers
a dye-levelling agent and a demulsifier
a reactive diluent in coatings
an RM in syntheses of polyurethanes and hyperbranched polyglycerols
a gelation agent in solid propellants

Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.

Amines>Alkanolamines
Polymerization>Polyglecerols
Methylamine >Glycidyl Methacrylate
C10/C12 FAME >Glycidyl Fatty Acid Esters
C10-C18 FAME & Fatty Alcohols>Glycidyl Ester & Ethers as non-ionic surfactants

MEDICAL APPLICATIONS
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.

CARDIAC AGENTS 
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers,  β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles  

APITHERAPEUTIC CATEGORY
AdrenalineHormone (for cardiovascular activities)
S-(-)-Atenololβ-blocker
Bufenololβ-blocker
Falintololβ-adrenergic receptor
Levobunololβ-Adrenergic blocker
S-(-)-Metoprololβ-blocker
Naipradilolβ-blocker
NoradrenalineVasopressor
Oxprenololβ-blocker
PropafenoneAntiarrhythmic
Propanololβ-blocker


 
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol

APITHERAPEUTIC CATEGORY
FexofenadineAntihistamine
GuaifenesinExpectorant
Indinavir SulfateAnti-Retroviral
LeinamycinAntibiotic
LevodropropizineAntitussive
MontelukastAnti-asthma
TenofovirAnti-Retroviral

BIOCHEMICAL PROBES  
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.

For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
 


SPECIFICATIONS

TESTUNITSPECIFICATION
AppearanceColorless liquid
Identification
· IRShould conform to the reference spectrum
H1NMRShould conform to the structure
Assay (by GC)  %Min 96.0
Water Content (by KF) Wt %Max 0.5


 
STORAGE
Recommended storage temperature is 2° to 8°C.

Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.



More Products in focus
In focus: Ginkgo Biloba Extract 24%
Products in focus · 10/06/2025

Ginkgo Biloba 24% extract is a standardized herbal formulation derived from the leaves of the Ginkgo biloba tree, one of the oldest living tree species. The “24%” typically refers to the content of flavone glycosides, while the product may also contain 6% terpene lactones. These active constituents are responsible for its medicinal properties.

READ MORE
In focus: 1,3-Dibromopropane
Products in focus · 03/06/2025

1,3-Dibromopropane is an organobromine compound.  A bifunctional alkyl halide, it has two bromine leaving groups that can participate in substitution or elimination reactions. It is widely used as a an intermediate in production of wide range of products including pharmaceuticals, insecticides, quaternary Ammonium compounds, flavouring agents ,fragrances and in polymer chemistry.

READ MORE
In focus: Tributyltin Hydride (Stabilized with BHT)
Products in focus · 27/05/2025

Tributyltin Hydride (TBT-H) stabilized with BHT (butylated hydroxytoluene) is a tin-based organometallic compound commonly used in organic synthesis, especially in radical reactions. It is air-sensitive and decomposes to tributyltin oxide in  presence of oxygen and light. It works by donating a hydrogen radical (H·) to a carbon radical intermediate.

READ MORE
In focus: Sodium Chloro Acetate
Products in focus · 20/05/2025

Sodium chloroacetate (chemical formula: CH₂ClCO₂Na) is a white, crystalline solid that is highly soluble in water and organic solvents like ethanol, chloroform, ether, and benzene. It is the sodium salt of chloroacetic acid and is prepared by treating chloroacetic acid with sodium carbonate

READ MORE
In focus: 2,4,6-Trimethylpyridine
Products in focus · 13/05/2025

2,4,6-Trimethylpyridine (also known as collidine) is a derivative of pyridine, featuring three methyl groups at the 2nd, 4th, and 6th positions. This compound is a colorless to yellow liquid with a strong, pungent odor. Due to its basicity and steric hindrance, it is widely used as a catalyst, solvent, and chemical intermediate in various industrial and pharmaceutical applications.

READ MORE
In focus: L-Phenylalanine USP
Products in focus · 06/05/2025

L-Phenylalanine (L-Phe) is an essential and  proteinogenic amino acid that helps build proteins and produces brain chemicals like dopamine and norepinephrine. L-Phenylalanine is one of the 20 standard amino acids that form long chains called polypeptides (proteins).The body cannot produce it, so it must be obtained through diet or supplements.

READ MORE
In focus: L – Carnitine Hydrochloride
Products in focus · 29/04/2025

L-carnitine Hydrochloride is a water soluble, stable salt form of L- Carnitine. It is a naturally occurring amino acid derivative.  It is often used as a dietary  supplement due to its role in energy production and fat metabolism.

READ MORE
In focus: Dimenhydrinate USP
Products in focus · 22/04/2025

Dimenhydrinate is an antihistamine drug commonly used to prevent and treat motion sickness, nausea, and vertigo. It is a combination of diphenhydramine and 8-chlorotheophylline, where the latter reduces the sedative effects of diphenhydramine. It is available in tablet, liquid, and injectable forms under various brand names.

READ MORE
In focus: o-Nitrophenyl Disulfide
Products in focus · 15/04/2025

o-Nitrophenyl Disulfide is a chemical compound used in organic chemistry and biochemistry. It is a disulfide derivative where two o-nitrophenyl groups are connected by a disulfide bond (-S-S-) It is used in various organic synthesis reactions, as a reagent in the preparation of thiol-reactive compounds, in pharmaceutical research and laboratory applications.

READ MORE