INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.
The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs. Glycidol has recently found use as a key component in a SARS COV2 testing kit.
| Synonyms: | Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane |
| CAS No.: | 556-52-5 |
| EINECS Number: | 209-128-3 |
| Molecular Formula: | C3H6O2 |
| Molecular Weight: | 74.08 |
| Structure: |  |
INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
| an epoxide building block |
| a stabilizer in PVC compounding |
| a stabilizer for natural oils and vinyl polymers |
| a dye-levelling agent and a demulsifier |
| a reactive diluent in coatings |
| an RM in syntheses of polyurethanes and hyperbranched polyglycerols |
| a gelation agent in solid propellants |
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
| Amines | > | Alkanolamines |
| Polymerization | > | Polyglecerols |
| Methylamine | > | Glycidyl Methacrylate |
| C10/C12 FAME | > | Glycidyl Fatty Acid Esters |
| C10-C18 FAME & Fatty Alcohols | > | Glycidyl Ester & Ethers as non-ionic surfactants |
MEDICAL APPLICATIONS
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.
CARDIAC AGENTS
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers, β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles
| API | THERAPEUTIC CATEGORY |
| Adrenaline | Hormone (for cardiovascular activities) |
| S-(-)-Atenolol | β-blocker |
| Bufenolol | β-blocker |
| Falintolol | β-adrenergic receptor |
| Levobunolol | β-Adrenergic blocker |
| S-(-)-Metoprolol | β-blocker |
| Naipradilol | β-blocker |
| Noradrenaline | Vasopressor |
| Oxprenolol | β-blocker |
| Propafenone | Antiarrhythmic |
| Propanolol | β-blocker |
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol
| API | THERAPEUTIC CATEGORY |
| Fexofenadine | Antihistamine |
| Guaifenesin | Expectorant |
| Indinavir Sulfate | Anti-Retroviral |
| Leinamycin | Antibiotic |
| Levodropropizine | Antitussive |
| Montelukast | Anti-asthma |
| Tenofovir | Anti-Retroviral |
BIOCHEMICAL PROBES
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.
For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | Colorless liquid |
| Identification | ||
| · IR | – | Should conform to the reference spectrum |
| H1NMR | – | Should conform to the structure |
| Assay (by GC) | % | Min 96.0 |
| Water Content (by KF) | Wt % | Max 0.5 |
STORAGE
Recommended storage temperature is 2° to 8°C.
Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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