INTRODUCTION

Calcium Gluconate is the calcium salt of gluconic acid, an oxidation product of glucose, and contains 9.3% calcium, which is about one-third of the calcium in the strength of calcium chloride. It is an ingredient found in a variety of supplements and vitamins and is used to lower potassium in the blood. Calcium gluconate is used as a mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia.

Manufacture
It is made by mixing gluconic acid with calcium carbonate or calcium hydroxide

SynonymsCalcium di-(D-gluconate)
D-Gluconic acid calcium salt
CAS no.299-28-5
EINECS no.206-075-8
Molecular formulaC12H22CaO14
Molecular weight430.37
Structure

Applications

Calcium gluconate is used to prevent or treat calcium deficiencies. Oral calcium salts are used as dietary supplemental therapy for people who may not get enough calcium in their regular diet
Calcium gluconate is used as a cardioprotective agent in high blood potassium
Calcium gluconate is the antidote for magnesium sulfate toxicity

Calcium gluconate is also used as/for:

Hyperkalemia
Hypocalcemia tetany
Dietary Supplement
Hungry Bone Syndrome
Tumor Lysis Syndrome

SPECIFICATIONS – for injection, EP

TestUnitSpecification
AppearanceWhite or almost white, crystalline or granular powder
SolubilitySparingly soluble in water, freely soluble in boiling water
Identification
A. TLC
B. Reaction of Calcium



Shall pass the test
Shall pass the test
Appearance of solutionAt 60°C, solution S is not more intensely colored than reference solution B7. After cooling to 20°C, it is not more opalescent than reference suspension II.
pHBetween 6.4 and 8.3
Organic impurities & Boric acidShall pass the test
OxalatesppmMax 100
Sucrose & reducing sugarsNo red precipitate is formed
ChloridesppmMax 50
PhosphatesppmMax 100
SulphatesppmMax 50
IronppmMax 5
Magnesium & alkali metals%Max 0.4
Assay as C12H22CaO14H2O%Between 99.0 and 101.0
Microbial Contamination
Bacterial endotoxinsIU/gMax 167
Total aerobic microbial countCFU/gMax 10(square)

STORAGE
Store in a cool & dry place. Keep away from moisture.

PACKING
25 kg drum.

REGISTRATION / CERTIFICATION
US-DMF, CEP, EU-GMP, EU-WC (Written Confirmation)

No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

More Products
In focus: Lycopene
Products in focus · 15/07/2025

Fungal Lycopene is an acyclic carotene belonging to a large group of naturally-occurring pigments known as carotenoids. It contains at least 90% of all-trans-lycopene and minor quantities of 13-cis-lycopene and β- and γ-carotene. It is used as an intermediate in the biosynthetic pathway of β-carotene. Its role in the pharmaceutical and food industries stems from its demonstrated health benefits—such as anticancer and cardiovascular protection—alongside its widespread use as a natural food colorant.

READ MORE
In focus: Methyl Tertiary Butyl Ether (MTBE) High Purity
Products in focus · 08/07/2025

Methyl Tertiary Butyl Ether (MTBE) is a high-purity chemical compound, typically exceeding 99.8% purity, widely valued for its use as a solvent and as an additive in fuels. It finds applications in pharmaceutical manufacturing, agrochemical and polymer production, as well as a solvent in extraction and recrystallization processes.

READ MORE
In focus: Berberine Hydrochloride
Products in focus · 01/07/2025

Berberine Hydrochloride is a yellow isoquinoline alkaloid extracted from various plants such as Berberis aristata, Coptis chinensis (Chinese goldthread), and Hydrastis canadensis (goldenseal). Berberine offered by ExSyn is from Berberis aristata. It is most commonly used in its hydrochloride salt form due to its better solubility and bioavailability. It is widely known for its antimicrobial, anti-inflammatory, and metabolic regulatory properties, and has gained popularity in nutraceutical and pharmaceutical industries.

READ MORE
In focus: Bromobenzene – d5
Products in focus · 24/06/2025

Bromobenzene-d5 is a perdeuterated form of bromobenzene(C6H5Br),  meaning all five hydrogen atoms in the benzene ring are replaced with deuterium (a stable isotope of hydrogen with one proton and one neutron). It is used as a stable isotope labeled compound, primarily in electronics industry, specifically in the production of OLED displays, in research applications, particularly in NMR spectroscopy and as a raw material in organic synthesis.

READ MORE
In focus: 2,2,2-Trifluoroethyl Methacrylate (Stabilized with MEHQ)
Products in focus · 17/06/2025

2,2,2-Trifluoroethyl Methacrylate (TFEMA) is a specialty methacrylate monomer featuring a trifluoromethyl (-CF₃) group. It is a colorless, highly reactive liquid stabilized with MEHQ. This compound is widely used in the synthesis of high-performance fluorinated polymers and TFEMA a valuable component in advanced applications such as protective coatings, optical materials, adhesives, electronics, and biomedical devices.

READ MORE
In focus: Ginkgo Biloba Extract 24%
Products in focus · 10/06/2025

Ginkgo Biloba 24% extract is a standardized herbal formulation derived from the leaves of the Ginkgo biloba tree, one of the oldest living tree species. The “24%” typically refers to the content of flavone glycosides, while the product may also contain 6% terpene lactones. These active constituents are responsible for its medicinal properties.

READ MORE
In focus: 1,3-Dibromopropane
Products in focus · 03/06/2025

1,3-Dibromopropane is an organobromine compound.  A bifunctional alkyl halide, it has two bromine leaving groups that can participate in substitution or elimination reactions. It is widely used as a an intermediate in production of wide range of products including pharmaceuticals, insecticides, quaternary Ammonium compounds, flavouring agents ,fragrances and in polymer chemistry.

READ MORE
In focus: Tributyltin Hydride (Stabilized with BHT)
Products in focus · 27/05/2025

Tributyltin Hydride (TBT-H) stabilized with BHT (butylated hydroxytoluene) is a tin-based organometallic compound commonly used in organic synthesis, especially in radical reactions. It is air-sensitive and decomposes to tributyltin oxide in  presence of oxygen and light. It works by donating a hydrogen radical (H·) to a carbon radical intermediate.

READ MORE
In focus: Sodium Chloro Acetate
Products in focus · 20/05/2025

Sodium chloroacetate (chemical formula: CH₂ClCO₂Na) is a white, crystalline solid that is highly soluble in water and organic solvents like ethanol, chloroform, ether, and benzene. It is the sodium salt of chloroacetic acid and is prepared by treating chloroacetic acid with sodium carbonate

READ MORE