INTRODUCTION
Berberine Hydrochloride is a yellow isoquinoline alkaloid extracted from various plants such as Berberis aristata, Coptis chinensis (Chinese goldthread), and Hydrastis canadensis (goldenseal). Berberine offered by ExSyn is from Berberis aristata. It is most commonly used in its hydrochloride salt form due to its better solubility and bioavailability. It is widely known for its antimicrobial, anti-inflammatory, and metabolic regulatory properties, and has gained popularity in nutraceutical and pharmaceutical industries.
Synonyms | Berberine chloride Benzodioxide; Natural Yellow 18 |
CAS no. | 633-65-8 |
EINECS no. | 211-195-9 |
Molecular formula | C₂₀H₁₈ClNO₄ |
Molecular weight | 371.82 |
Structure | ![]() |
MANUFACTURE |
---|
1. Raw Material Extraction |
• Source Plants: Rhizomes or roots of plant Berberis. |
• Extraction Solvent: Typically, ethanol or water is used under heat and pressure to extract the crude alkaloids. |
2. Alkaloid Isolation |
• The crude extract undergoes acid-base purification to isolate berberine. |
3. Purification & Crystallization |
• The berberine hydrochloride is further recrystallized to achieve pharmaceutical grade purity. |
• Drying and milling are done to obtain the final yellow crystalline powder. |
Key features of Berberine offered by ExSyn: |
---|
100% vegan |
Superior bioavailability & efficacy |
Excipient free |
Powered by OMICS technology |
Clinically validated |
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | Yellow colour |
Form | – | Granules |
Taste | – | Characteristic Taste |
Odour | – | Characteristic Odour |
Ingredients | ||
Berberine HCl (Berberis aristate) | % | NLT 85.0 |
Aqueous Extract of Berberis aristate | % | NLT 5.0 |
Milk Thistle Extract (Silybum marianum L.) | % | NLT 5.0 |
Particle Size | % | NLT 80.0 pass through 30# |
Cadmium (Cd) | ppm | NMT 1.0 |
Arsenic (As) | ppm | NMT 1.0 |
Mercury (Hg) | ppm | NMT 0.1 |
Lead (Pb) | ppm | NMT 3.0 |
Total Plate Count | cfu/ g | NMT 1000 |
Yeast and mould | cfu/ g | NMT 100 |
E. coli | – | Should be absent / g |
Salmonella | – | Should be absent/ 25g |
S. aureus | – | Should be absent/ g |
APPLICATIONS |
---|
With a traditional history in Chinese and Ayurvedic medicine and growing modern scientific validation, Berberine’s use in pharmaceuticals and nutraceuticals continues to expand. |
Pharmaceutical Applications |
Type 2 Diabetes Management: Lowers blood glucose levels by activating AMP-activated protein kinase (AMPK). |
Hyperlipidemia: Reduces cholesterol and triglyceride levels. |
Anti-inflammatory and Antioxidant: Inhibits pro-inflammatory cytokines and oxidative stress. |
Antimicrobial: Effective against bacteria (e.g., E. coli, Staphylococcus aureus), fungi, and protozoa. |
Gastrointestinal Health: Treats diarrhea, IBS, and H. pylori infection. |
Nutraceuticals and Dietary Supplements |
Commonly used in capsule or tablet form as a metabolic support supplement. |
Marketed for weight management, insulin sensitivity, and cardiovascular support. |
Cosmetics and Personal Care |
Sometimes included in herbal cosmetic formulations for its antibacterial and skin-soothing properties. |
Veterinary Medicine |
Used in herbal preparations for digestive and metabolic issues in animals. |
PACKING
2kg net weight in poly bag, placed in an export worthy HDPE drum.
STORAGE
Store at ambient temperature.
CERTIFICATIONS
GMP, HALAL, KOSHER.
ExSyn offers Berberine on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
5-Methyl-3-vinyl-2-oxazolidinone (V-MOX) is a highly reactive monomer valued for its low viscosity, mild odor, and excellent reactivity. It is widely used as a reactive diluent in UV-curable inks and coatings, where it enhances adhesion, produces brighter colors, and improves safety compared to conventional diluents. In addition, V-MOX serves as a key building block in the synthesis of kinetic hydrate inhibitor (KHI) polymers, which are applied in oil and gas production to prevent hydrate blockages in pipelines.
Zinc ricinoleate is the zinc salt of ricinoleic acid, a hydroxylated fatty acid derived mainly from castor oil (Ricinus communis). It appears as a white to slightly yellowish powder, waxy solid, or paste, depending on formulation. Its most valuable property is its ability to trap and absorb odor molecules such as amines, sulfides, and short-chain fatty acids, making it an essential ingredient in deodorant and odor-control products.
2-(tert-Butyl amino)ethyl methacrylate (TBAEMA) is a functional methacrylate monomer that contains a secondary amine group and a hydrophobic tert-butyl moiety, giving it excellent versatility in pH-responsive and adhesion-enhancing polymer systems.
It is valued in printing ink formulations for its ability to enhance adhesion, flexibility, and surface interaction.
Commonly known as potassium bis(fluorosulfonyl)imide (KFSI), the compound has a three-carbon backbone bearing six fluorine atoms and two sulfonimide (-SO₂F) groups. The molecule’s architecture lends it both high chemical stability and useful reactivity. Because of its excellent ionic conductivity and thermal / electrochemical stability, it finds use in advanced electrolyte formulations—for example in lithium-ion and next-generation batteries, in ionic liquids, and in other electrochemical systems.
Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.
1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.
Atropine sulfate monohydrate is a chemical compound, specifically a salt of atropine and sulfuric acid, with one water molecule (monohydrate) attached. It is commonly used as a medication and in research due to its anticholinergic properties, meaning it blocks the effects of acetylcholine at muscarinic receptors.
4-Aminobenzoic acid, commonly abbreviated as PABA, is an aromatic amine and carboxylic acid compound. It consists of a benzene ring substituted with an amino group (–NH₂) in the para position to a carboxylic acid group (–COOH).
2-Amino-5-Nitrophenol (5-NAP) is an organic compound with the molecular formula C₆H₆N₂O₃. It is a substituted phenol with both an amino group (-NH₂) and a nitro group (-NO₂) attached to a benzene ring, along with a hydroxyl group (-OH).