INTRODUCTION
Berberine Hydrochloride is a yellow isoquinoline alkaloid extracted from various plants such as Berberis aristata, Coptis chinensis (Chinese goldthread), and Hydrastis canadensis (goldenseal). Berberine offered by ExSyn is from Berberis aristata. It is most commonly used in its hydrochloride salt form due to its better solubility and bioavailability. It is widely known for its antimicrobial, anti-inflammatory, and metabolic regulatory properties, and has gained popularity in nutraceutical and pharmaceutical industries.
| Synonyms | Berberine chloride Benzodioxide; Natural Yellow 18 |
| CAS no. | 633-65-8 |
| EINECS no. | 211-195-9 |
| Molecular formula | C₂₀H₁₈ClNO₄ |
| Molecular weight | 371.82 |
| Structure |  |
| MANUFACTURE |
|---|
| 1. Raw Material Extraction |
| • Source Plants: Rhizomes or roots of plant Berberis. |
| • Extraction Solvent: Typically, ethanol or water is used under heat and pressure to extract the crude alkaloids. |
| 2. Alkaloid Isolation |
| • The crude extract undergoes acid-base purification to isolate berberine. |
| 3. Purification & Crystallization |
| • The berberine hydrochloride is further recrystallized to achieve pharmaceutical grade purity. |
| • Drying and milling are done to obtain the final yellow crystalline powder. |
| Key features of Berberine offered by ExSyn: |
|---|
| 100% vegan |
| Superior bioavailability & efficacy |
| Excipient free |
| Powered by OMICS technology |
| Clinically validated |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Yellow colour |
| Form | – | Granules |
| Taste | – | Characteristic Taste |
| Odour | – | Characteristic Odour |
| Ingredients | ||
| Berberine HCl (Berberis aristate) | % | NLT 85.0 |
| Aqueous Extract of Berberis aristate | % | NLT 5.0 |
| Milk Thistle Extract (Silybum marianum L.) | % | NLT 5.0 |
| Particle Size | % | NLT 80.0 pass through 30# |
| Cadmium (Cd) | ppm | NMT 1.0 |
| Arsenic (As) | ppm | NMT 1.0 |
| Mercury (Hg) | ppm | NMT 0.1 |
| Lead (Pb) | ppm | NMT 3.0 |
| Total Plate Count | cfu/ g | NMT 1000 |
| Yeast and mould | cfu/ g | NMT 100 |
| E. coli | – | Should be absent / g |
| Salmonella | – | Should be absent/ 25g |
| S. aureus | – | Should be absent/ g |
| APPLICATIONS |
|---|
| With a traditional history in Chinese and Ayurvedic medicine and growing modern scientific validation, Berberine’s use in pharmaceuticals and nutraceuticals continues to expand. |
| Pharmaceutical Applications |
| Type 2 Diabetes Management: Lowers blood glucose levels by activating AMP-activated protein kinase (AMPK). |
| Hyperlipidemia: Reduces cholesterol and triglyceride levels. |
| Anti-inflammatory and Antioxidant: Inhibits pro-inflammatory cytokines and oxidative stress. |
| Antimicrobial: Effective against bacteria (e.g., E. coli, Staphylococcus aureus), fungi, and protozoa. |
| Gastrointestinal Health: Treats diarrhea, IBS, and H. pylori infection. |
| Nutraceuticals and Dietary Supplements |
| Commonly used in capsule or tablet form as a metabolic support supplement. |
| Marketed for weight management, insulin sensitivity, and cardiovascular support. |
| Cosmetics and Personal Care |
| Sometimes included in herbal cosmetic formulations for its antibacterial and skin-soothing properties. |
| Veterinary Medicine |
| Used in herbal preparations for digestive and metabolic issues in animals. |
PACKING
2kg net weight in poly bag, placed in an export worthy HDPE drum.
STORAGE
Store at ambient temperature.
CERTIFICATIONS
GMP, HALAL, KOSHER.
ExSyn offers Berberine on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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