INTRODUCTION

4’-Cyanoacetophenone is an organic solid. It belongs to cyclic nitriles category. The presence of cyano group makes the compound reactive to form various intermediates and a few APIs. In organics syntheses, it also used as a catalyst.

Manufacture

It is manufactured by acetylation of benzonitrile with acetic anhydride in presence of a catalyst.

Synonym4-Acetylbenzonitrile
4-Cyanophenyl methyl ketone
CAS no.1443-80-7
EINECS no.215-885-0
Molecular formulaC9H7NO
Molecular weight145.16
Structure

Applications

API – The nitrile is a KRM for:
Ravuconazole, an anti-fungal
Isovucanozole, also an anti-fungal
Antimalarial isonitriles
Some anesthetic and antiallergic agents
Intermediates – It is also used in manufacture of intermediates such as:
4-(1,2,3-thiodiazyl-4-yl)benzoyl chloride
4-(1,2,3-thiodiazyl-4-yl)benzonitrile
(S)-1-(4-cyanophenyl)ethanamine
4-Cyanophenylglyoxal hydrate
1-Bromo-4-cyanoacetophenone
4-Acetylbenozoic acid
Others
As additive in fuel and lubricant formulations
Uses in polymers and fragrances are cited in the literature

SPECIFICATIONS

TestUnitSpecifications
AppearanceOff-white to pale yellow crystalline powder
Identification by IRShould conform with standard
SolubilitySoluble in methanol and chloroform
Melting range°C55.0 – 58.0
Loss on drying% w/wMax 0.50
Purity by GC% áreaMin 98.0

STORAGE

Stored at ambient temperature

PACKING

25 kg HDPE drum

REACH Status

Not registered

ExSyn offers 4’-cyanoacetophenone on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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