INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
CAS no. | 108-48-5 |
EINECS no. | 203-587-3 |
Molecular formula | C7H9N |
Molecular weight | 107.15 |
Structure | ![]() |
Applications in APIs
The dialkylated pyridine is a KRM for production of APIs: |
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Clopidol – a veterinary medicine, used as coccidiostat. |
Cefpiramide acid – an antibiotic |
Applications in Intermediates
Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
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2,6-Dimethylpiperidine |
Dipicolinic acid |
2,6-Dimethylpyridine-4-amine |
2-Bromomethyl-6-methylpyridine |
2,6-Dimethylpyridine-N-oxide |
Other Applications
As a sterically hindered mild base in organic syntheses |
Used as food additive to impart nutty odor and flavor |
Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
Test | Unit | Specification |
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Appearance | – | Monophase clear colorless liquid with no foreign impurities |
Solubility | – | Soluble in methanol and cold water |
Boiling point | °C | 144-145 |
Color | APHA | Max 20 |
Moisture by KF | % | Max 0.2 |
Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
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