INTRODUCTION
2-Bromonitrobenzene is an aromatic compound and a pale-yellow powder that easily absorbs moisture. By virtue of its rather low melting point, it may appear as semi-liquid under high ambient temperatures. The nitro-group containing haloaromatic has numerous end-uses in pharmaceuticals, value-added intermediates, and other industry verticals.
Manufacture
| Its production involves 2 steps: |
|---|
| First, 2-nitroaniline is diazotized in presence of cuprous bromide. |
| In the second step, excess copper salt is removed to yield 2-bromonitrobenzene. |
| Synonyms | 2-Nitrobromobenzene 2-Nitrophenyl bromide |
| CAS no. | 577-19-5 |
| EINECS no. | 209-409-0 |
| Molecular formula | C6H4BrNO2 |
| Molecular weight | 202.01 |
| Structure |  |
Applications in APIs
The aromatic is consumed in a process that results into diarylamino-1,3,5-triazine derivative, which in turn possesses anti-angiogenic activity.
Applications in Intermediate Syntheses
2-Bromonitrobenzene is consumed in synthesis of intermediate products such as:
| N-methyl-N-(2-nitrphenyl)anthranilic acid |
| 4-Methoxy-2-nitrodiphenyl ether |
| 1-Methoxy-3,5-bis-(2-nitrophenoxy)benzene |
| 1-(2-Nitrophenyl)piperidine |
| 2-Aminodiphenylamine |
| 2-Bromo-1,3-dinitrobenzene |
| 2-Bromo-6-nitrophenol |
| Methyl 2-nitrobenzoate |
| 2-Methoxy-9H-carbazole |
| 3-Bromo-4-nitroaniline |
| 2-Nitro-4-(hydroxyethyl)aniline |
| 4-Hydroxy-2-methylquinoline |
| 5-Hydroxy-3-methoxy-2’-nitrodiphenyl ether |
Other Applications
The aromatic exhibits further versatility as:
| Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis |
| Dehydrating agent to convert amides into nitriles |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Pale to light yellow powder |
| Purity by GC | % | Min 99.5 |
STORAGE
The product is stored at ambient temperature.
PACKING
5 x 5 kg HDPE bags in 50 liters UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2-bromonitrobenzene on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Methyl magnesium chloride is the simplest of Grignard’s reagents. The neat molecule is sensitive to air and moisture. Therefore, it is offered as solution in THF with variable molarity values.
Polysorbate 20 is a gentle, oily, liquid cosmetic additive that functions as a non-ionic surfactant and wetting agent that enhances the spread-ability of liquids.
Iodomethane, also known as methyl iodide, is a colorless, non-flammable liquid with pungent, ethereal odor that darkens on exposure to light. It occurs naturally in oceans as a product of marine algae.
1,4-Dibromobutane is a chemical compound from the group of aliphatic, saturated halogenated hydrocarbons. 1,4-Dibromobutane shows similar reactions as the mono-brominated 1-bromobutane, however, in contrast, it is doubly functionalized.
Tetrabutylammonium fluoride trihydrate (TBAF trihydrate) is a hygroscopic solid and is a versatile reagent in many chemical reactions. It us usually consumed in aldol-type condensation, Michael-type, and ring opening reactions.
Pyrophosphoryl chloride is colourless to pale yellow liquid, reasonably easy to handle. It reacts violently with water & miscible with most organic solvents.
It is used in pharmaceutical and other organic synthesis, as laser materials and electronic components.
Benzilic acid ethyl ester is an oil organic liquid. Its reactivity is attributed to the presence of the hydroxyl group at alpha-position to the carboxylic acid group and hence it participates in various reactions leading to value-added intermediates and APIs.
Bromobenzene, an aryl halide, is a clear, colorless liquid with a pleasant odor. It is soluble in methanol and diethyl ether, and very slightly soluble in cold water.
Dibutyltin laurate is an organotin compound with oily appearance. The lauric acid ester is used in various industrial applications as catalyst.