INTRODUCTION
2-Bromonitrobenzene is an aromatic compound and a pale-yellow powder that easily absorbs moisture. By virtue of its rather low melting point, it may appear as semi-liquid under high ambient temperatures. The nitro-group containing haloaromatic has numerous end-uses in pharmaceuticals, value-added intermediates, and other industry verticals.
Manufacture
| Its production involves 2 steps: |
|---|
| First, 2-nitroaniline is diazotized in presence of cuprous bromide. |
| In the second step, excess copper salt is removed to yield 2-bromonitrobenzene. |
| Synonyms | 2-Nitrobromobenzene 2-Nitrophenyl bromide |
| CAS no. | 577-19-5 |
| EINECS no. | 209-409-0 |
| Molecular formula | C6H4BrNO2 |
| Molecular weight | 202.01 |
| Structure |  |
Applications in APIs
The aromatic is consumed in a process that results into diarylamino-1,3,5-triazine derivative, which in turn possesses anti-angiogenic activity.
Applications in Intermediate Syntheses
2-Bromonitrobenzene is consumed in synthesis of intermediate products such as:
| N-methyl-N-(2-nitrphenyl)anthranilic acid |
| 4-Methoxy-2-nitrodiphenyl ether |
| 1-Methoxy-3,5-bis-(2-nitrophenoxy)benzene |
| 1-(2-Nitrophenyl)piperidine |
| 2-Aminodiphenylamine |
| 2-Bromo-1,3-dinitrobenzene |
| 2-Bromo-6-nitrophenol |
| Methyl 2-nitrobenzoate |
| 2-Methoxy-9H-carbazole |
| 3-Bromo-4-nitroaniline |
| 2-Nitro-4-(hydroxyethyl)aniline |
| 4-Hydroxy-2-methylquinoline |
| 5-Hydroxy-3-methoxy-2’-nitrodiphenyl ether |
Other Applications
The aromatic exhibits further versatility as:
| Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis |
| Dehydrating agent to convert amides into nitriles |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Pale to light yellow powder |
| Purity by GC | % | Min 99.5 |
STORAGE
The product is stored at ambient temperature.
PACKING
5 x 5 kg HDPE bags in 50 liters UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2-bromonitrobenzene on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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