INTRODUCTION
Dichloroacetic acid is an organochlorine compound and a corrosive liquid with ammoniacal odor. Its natural occurrence is in seaweeds.
The compound is a versatile chemical reagent. It also possesses medicinal properties and is used as such to treat lactic acidosis, whereby it stems production of lactic acid. It is also employed as a disinfectant.
Manufacture
Dichloroacetic acid is commercially produced as a by-product in chlorination of acetic acid, the main product being chloroacetic acid.
| Synonyms | Bichloroacetic acid 2,2-Dichloroacetic acid |
| CAS no. | 79-43-6 |
| EINECS no. | 201-207-0 |
| Molecular formula | C2H2Cl2O2 |
| Molecular weight | 128.95 |
| Structure |  |
Applications
| Medicinal | As an astringent. Its salts are used as drugs in inhibition of the enzyme Pyruvate Dehydrogenase Kinase. |
| Pharmaceutical | Dichloroacetic acid forms a starting raw material in the manufacture of API Chloramphenicol. |
| Agrochemical | The dihalogenated acid is a key intermediate in production of the herbicide Dichlormid. |
| Other Vital | The compound acts as a detritylation agent in nucleic acid syntheses. It also finds application in peptide production. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to light yellow liquid |
| Water by KF | % w/w | Max 0.05 |
| Assay by titration | % | Min 99.0 |
| Assay by derivative GC | % | Min 99.0 |
| Impurities by GC: | ||
| 1. Chloroacetic acid | % | Max 1.0 |
| 2. Trichloroacetic acid | % | Max 1.0 |
STORAGE
Product is stored at ambient temperature.
PACKING
40 kg & 250 kg HDPE drums.
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