INTRODUCTION
2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.
Manufacture
The synthesis method of 2-chloroethylamine hydrochloride mainly comprises a synthesis method of ethanolamine hydrochloride and thionyl chloride and a synthesis method of ethanolamine and hydrogen chloride.
| Synonym | 2-Aminoethyl chloride hydrochloride |
| CAS no. | 870-24-6 |
| EINECS no. | 212-793-2 |
| Molecular formula | C2H7Cl2N |
| Molecular weight | 115.99 |
| Structure |  |
| APPLICATIONS |
|---|
| Used as an intermediate in APIs * Ifosfamide – cytotoxic, antineoplastic * Fluvoxamine maleate – antidepressant |
| Used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. |
| Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents. |
| Further, it is employed as a derivatizing reagent for amino acids, dipeptides and nucleotides. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Description | – | White to off white powder |
| Solubility | – | Soluble in wáter and methanol |
| Identification (by IR) | – | IR spectrum of the sample should correspond to that of the standard |
| Water content | % w/w | NMT 1.0 |
| Ionic Chloride | % w/w | 29.0 – 32.1 |
| Assay (by Titrimetry – on anhydrous basis) | % w/w | 98.0 – 102.0 |
PACKING
25 kg UN approved HDPE bag/drum.
STORAGE
Store in original container, protected from light and heat.
REACH Status
Not registered yet.
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