INTRODUCTION
Tributyltin Hydride (TBT-H) stabilized with BHT (butylated hydroxytoluene) is a tin-based organometallic compound commonly used in organic synthesis, especially in radical reactions. It is air-sensitive and decomposes to tributyltin oxide in presence of oxygen and light. It works by donating a hydrogen radical (H·) to a carbon radical intermediate.
MANUFACTURE
Synthesis involves two common methods of reduction reactions;
Reduction of Tributyltin Oxide with polymethylhydrosiloxane
Reduction of Tributyltin Chloride using lithium aluminium hydride.
The crude product is further purified by distillation process.
| Synonyms | Tributylstannane; Tri-n- butyltin hydride, SnBu3H |
| CAS no. | 688-73-3 |
| EINECS no. | 211-704-4 |
| Molecular formula | C12H28Sn |
| Molecular weight | 291.06 |
| Structure |  |
APPLICATIONS
(TBT-H) is a versatile reagent used in organic synthesis, particularly in radical dehalogenation and radical cyclization reactions.
| Tributyltin hydride is a key reagent in radical reactions, acting as a hydrogen source for various transformations. |
| It can reduce organic halides to alkanes through a radical chain mechanism. |
| Used to deprotect highly stable N-sulfonamides to the respective amides under mild conditions. |
| As a reagent of choice for hydrostannylation reactions, where it can add a tin atom to an alkyne. |
| Also used in aryl radical cyclization reactions. |
| It finds applications in the pharmaceutical industry as a synthetic reagent. |
SPECIFICATIONS – USP
| Test | Unit | Specification |
|---|---|---|
| Description | – | Clear, slightly hazy colorless to pale yellow color liquid |
| Solubility | – | Miscible with Isopropyl Alcohol and Tetrahydrofuran |
| Weight per ml (At 25 °C ± 1) | g/ml | 1.070 – 1.090 |
| Chromatographic Purity (By GC)(Without BHT) | % Area | NLT 96.0 |
STORAGE & PRECAUTION
Store between 2-8°C temperature under Nitrogen atmosphere. Keep the container tightly closed in a dry and well-ventilated place.
Shipped under temperature-controlled conditions.
PACKING
50 Kgs Composite drums.
REACH Status
Not registered.
ExSyn offers Tributyltin hydride (stabilized with BHT) on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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