INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.
The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs. Glycidol has recently found use as a key component in a SARS COV2 testing kit.
Synonyms: | Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane |
CAS No.: | 556-52-5 |
EINECS Number: | 209-128-3 |
Molecular Formula: | C3H6O2 |
Molecular Weight: | 74.08 |
Structure: |
INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
an epoxide building block |
a stabilizer in PVC compounding |
a stabilizer for natural oils and vinyl polymers |
a dye-levelling agent and a demulsifier |
a reactive diluent in coatings |
an RM in syntheses of polyurethanes and hyperbranched polyglycerols |
a gelation agent in solid propellants |
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
Amines | > | Alkanolamines |
Polymerization | > | Polyglecerols |
Methylamine | > | Glycidyl Methacrylate |
C10/C12 FAME | > | Glycidyl Fatty Acid Esters |
C10-C18 FAME & Fatty Alcohols | > | Glycidyl Ester & Ethers as non-ionic surfactants |
MEDICAL APPLICATIONS
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.
CARDIAC AGENTS
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers, β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles
API | THERAPEUTIC CATEGORY |
Adrenaline | Hormone (for cardiovascular activities) |
S-(-)-Atenolol | β-blocker |
Bufenolol | β-blocker |
Falintolol | β-adrenergic receptor |
Levobunolol | β-Adrenergic blocker |
S-(-)-Metoprolol | β-blocker |
Naipradilol | β-blocker |
Noradrenaline | Vasopressor |
Oxprenolol | β-blocker |
Propafenone | Antiarrhythmic |
Propanolol | β-blocker |
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol
API | THERAPEUTIC CATEGORY |
Fexofenadine | Antihistamine |
Guaifenesin | Expectorant |
Indinavir Sulfate | Anti-Retroviral |
Leinamycin | Antibiotic |
Levodropropizine | Antitussive |
Montelukast | Anti-asthma |
Tenofovir | Anti-Retroviral |
BIOCHEMICAL PROBES
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.
For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
SPECIFICATIONS
TEST | UNIT | SPECIFICATION |
---|---|---|
Appearance | – | Colorless liquid |
Identification | ||
· IR | – | Should conform to the reference spectrum |
H1NMR | – | Should conform to the structure |
Assay (by GC) | % | Min 96.0 |
Water Content (by KF) | Wt % | Max 0.5 |
STORAGE
Recommended storage temperature is 2° to 8°C.
Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Boron trifluoride tetrahydrofuran complex, is a colorless liquid that is commonly used as a colorless liquid that is commonly used as a Lewis acid catalyst in various organic reactions. It has a wide range of applications in the synthesis of pharmaceuticals, polymers, and other organic compounds
Nicotinamide riboside chloride (NRCL) is a unique form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, it has sparked interest in the realms of aging, metabolism, and overall cellular health.
Tetrachlorvinphos (popularly known as TCVP) is an agrochemical belonging to class of organophosphates. It is a non-systemic insecticide and acaracide having widespread uses in crop protection, public health, and animal hygiene.
Sodium Starch Glycolate (SSG) is a very fine free flowing powder that is white or off white in color and has almost no odor. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. It is a sodium salt of carboxyl ether of starch and is appreciated for its stability and binding properties.
3-([Ethyl(3-methylphenyl)amino]methyl) benzenesulfonic acid is an organic sulfonic acid, a white crystalline solid, which is widely used as a catalyst, acidifying agent, and a reagent in organic synthesis.
Sodium trifluoroacetate is a colorless organic solid belonging to category of fluoro compounds. It acts as a versatile trifluoromethylation agent in chemicals synthesis and is used to produce an array of chemical intermediates.
Iodopropynyl butylcarbamate, also known as IPBC, is an antimicrobial ingredient commonly used in cosmetics. It appears as a white, crystalline powder. It is not a paraben; it belongs to a different chemical class called carbamates. It is soluble in both water and oil-based systems. IPBC was invented in the 1970s and has a long history of effective use as an antifungal technology.
Stevia extract with Rebaudioside A (98%) is one of the sweet tasting steviol glycoside, extracted and purified from Stevia rebaudiana (Bertoni) – a small perennial shrub also known as “Honey leaf”. The leaves of S. rebaudiana contain more than 30 different steviol glycosides, among which stevioside and rebaudioside A are present in the highest levels. It is non-nutritive and tastes approximately 200-300 times sweeter than sucrose.
Protoporphyrin IX dimethyl ester, abbreviated PPMX, is an organic moiety belonging to category porphyrins. On exposure to light, PPMX releases reactive oxygen that can be used to destroy targeted cancer cells and thus it find applications largely in medicines.