INTRODUCTION
4’-Cyanoacetophenone is an organic solid. It belongs to cyclic nitriles category. The presence of cyano group makes the compound reactive to form various intermediates and a few APIs. In organics syntheses, it also used as a catalyst.
Manufacture
It is manufactured by acetylation of benzonitrile with acetic anhydride in presence of a catalyst.
| Synonym | 4-Acetylbenzonitrile 4-Cyanophenyl methyl ketone |
| CAS no. | 1443-80-7 |
| EINECS no. | 215-885-0 |
| Molecular formula | C9H7NO |
| Molecular weight | 145.16 |
| Structure |  |
Applications
| API – The nitrile is a KRM for: |
|---|
| Ravuconazole, an anti-fungal |
| Isovucanozole, also an anti-fungal |
| Antimalarial isonitriles |
| Some anesthetic and antiallergic agents |
| Intermediates – It is also used in manufacture of intermediates such as: |
|---|
| 4-(1,2,3-thiodiazyl-4-yl)benzoyl chloride |
| 4-(1,2,3-thiodiazyl-4-yl)benzonitrile |
| (S)-1-(4-cyanophenyl)ethanamine |
| 4-Cyanophenylglyoxal hydrate |
| 1-Bromo-4-cyanoacetophenone |
| 4-Acetylbenozoic acid |
| Others |
|---|
| As additive in fuel and lubricant formulations |
| Uses in polymers and fragrances are cited in the literature |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Off-white to pale yellow crystalline powder |
| Identification by IR | – | Should conform with standard |
| Solubility | – | Soluble in methanol and chloroform |
| Melting range | °C | 55.0 – 58.0 |
| Loss on drying | % w/w | Max 0.50 |
| Purity by GC | % área | Min 98.0 |
STORAGE
Stored at ambient temperature
PACKING
25 kg HDPE drum
REACH Status
Not registered
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