INTRODUCTION
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure. The compound undergoes various reactions to form APIs and intermediates.
Manufacture
It is manufactured from N.N’-dicyclohexylurea either by using phosphorous oxychloride or phosphorous pentoxide.
| Synonyms | DCCD Carbodicyclohexylimide |
| CAS no. | 538-75-0 |
| EINECS no. | 208-704-1 |
| Molecular formula | C13H22N2 |
| Molecular weight | 206.33 |
| Structure |  |
Applications
| APIs: The diimide is used in the synthesis of APIs such as |
|---|
| Benexate HCl, an anti-ulcer drug |
| Angiotensin II, an anti-hypertensive drug and a peptide hormone |
| Docetaxel, an anti-cancer drug, also used in treatment of chronic heart failures |
| Intermediates: DCCD is used as a reagent in the synthesis of intermediates like |
|---|
| 2-Cyanopyridine-4-carboxaldehyde |
| Gly-7-amino-4-methylcoumarin |
| (S)-3-Aminoquinuclidine dihydrochloride |
| Others: |
|---|
| As dehydrating agent |
| As coupling agent in APIs and peptides |
| In synthesis of acid anhydrides, aldehydes, ketones, and isocyanates |
| In inversion and esterification of secondary alcohols |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Colorless to pale yellow liquid to semi-solid |
| Identification by GC | – | The retention time of the major peak in the chromatogram of the sample solution corresponds to that in the chromatogram of the standard solution |
| Solubility | – | Soluble in methanol and sparingly soluble in acetone |
| Purity by GC | % | Min 99.0 |
STORAGE
Stored at ambient temperature.
PACKING
35 kg UN approved Jerrycan.
REACH Status
Not registered yet.
ExSyn offers N,N’-dicyclohexylcarbodiimide on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.
The product, acronymed ETD, is an organic compound with a fused bicyclic ring system and an ethylidene group. The structure renders the chemical special properties leading to its applications in diverse fields.
Sodium perchlorate monohydrate is the inorganic compound with the chemical formula NaClO4•H2O. It is the common existence form of sodium perchlorate, which can gradually absorb water in the air to form the monohydrate. Sodium perchlorate monohydrate is white rhombic crystal which is highly soluble in water and in alcohol. Its capacity to undergo redox reactions, liberating oxygen atoms, has been harnessed in the preparation of specialty chemicals, including pharmaceutical intermediates and fine chemicals.
Triphenylphosphine is a common organophosphorus compound that is frequently abbreviated as PPh3 or Ph3P. It is widely used in organic and organometallic compound synthesis because it is an effective reducing agent as well as a neutral ligand. At room temperature, PPh3 crystals are relatively air-stable and colourless.
Potassium chlorate holds significant importance across various industries due to its diverse applications. This white crystalline compound has been utilized for centuries as an essential ingredient in the production of matches, fireworks, and explosives, owing to its ability to release oxygen upon decomposition.
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It is an organic heterotetracyclic compound that has a Furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
Octadecylphosphonic acid (ODPA), a versatile chemical compound, serves as a surfactant and dispersant in applications spanning coatings, lubricants, and corrosion inhibition. With its hydrophobic octadecyl chain linked to a phosphonic acid group, it excels in surface modification, boosting adhesion in metal surfaces.
2-(Benzylmethylamino)-1-phenylpropanone is an organics intermediate from ketone category. It is a compound with notable pharmacological potential and itself has excellent cytotoxic properties. In trade, the chemicals is referred to as AMK.
Budesonide is in a class of medications called corticosteroids. It works by decreasing inflammation (swelling) in the digestive tract of people who have Crohn’s disease or ulcerative colitis. or in the kidney of people with nephropathy.