INTRODUCTION
Racemic quinuclidinol is an off-white solid that possesses medicinal properties. It is an alkaloid abundant in nature, especially in Erythroxylum coca. Synthetically manufactured product finds usage in APIs, intermediates, and medicinal chemistry.
Manufacture
It is commercially manufactured by optical resolution of 3-quinuclidinol, the by-product being (R)-(-)-3-quinuclidinol.
| Synonym | S-3-Quinuclidinol (S)-3-Hydroxyquinuclidine (3S)-1-Azabicyclo[2.2.2]octan-3-ol |
| CAS no. | 34583-34-1 |
| EINECS no. | 681-383-7 |
| Molecular formula | C7H13NO |
| Molecular weight | 127.18 |
| Structure |  |
Applications
| Quinuclidinol is used in the manufacture of following APIs |
|---|
| Solifenacin HCl, treats urinary inconsistence |
| Clidinium, an anticholinergic drug |
| Umeclidinium, to treat shortness of breath |
| Penehyclidine HCl, a selective anticholinergic |
| Solifenacin succinate, an antimuscarinic agent |
| Intermediates |
|---|
| (S)-(-)-3-Aminoquinuclidine HCl |
| Others |
|---|
| As reagent in chemoselective alpha-iodination of acrylic esters and for cleavage of beta-keto esters |
| As synthon for preparation of cholinergic receptor ligands and anesthetics |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Cream coloured to off-white solid |
| Melting range | °C | 210.0 – 220.0 |
| LOD at 50 °C | % | Max 1.0 |
| Purity by GC | % | Min 95.0 |
| Purity by Chiral HPLC | % | Min 99.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 kg UN approved HDPE drum.
REACH Status
Not registered yet.
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