INTRODUCTION
Pyrophosphoryl chloride is colourless to pale yellow liquid, reasonably easy to handle. It reacts violently with water & miscible with most organic solvents.
It is used in pharmaceutical and other organic synthesis, as laser materials and electronic components.
Manufacture
Pyrophosphoryl chloride is prepared by reacting dichlorophosphoric acid, or a mixture containing the acid with phosphorus pentachloride in the absence of water.
| Synonyms | Pyrophosphoric tetrachloride Pyrophosphoryl chloride Diphosphoric tetrachloride |
| CAS no. | 13498-14-1 |
| EINECS no. | 236-824-4 |
| Molecular formula | P2O3Cl4 |
| Molecular weight | 251.76 |
| Structure |  |
Applications
| Pyrophosphoryl chloride serves as a reductive chlorination reagent used in the synthesis of quetiapine. |
| It acts as a phosphorylating agent involved in nucleoside synthesis. |
| It plays an important role in Vilsmeier formylation and glyoxylation reactions. |
| Diphosphoryl chloride is used in the synthesis of potent and orally bioavailable tricyclic CGRP receptor antagonists. |
| Also used in the synthesis of transition state analogue inhbitors of inosine monophosphate. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Characteristics | – | Colorless, smoking, corrosive liquid |
| Specific gravity | – | 1.80 – 1.82 |
| Assay by Chloride | % | Min 99.0 |
| Assay by Acidimetric | % | Min 99.0 |
STORAGE
Moisture Sensitive. Air Sensitive. Store under Nitrogen. Ambient temperatures.
PACKING
40 kg UN approved carboys.
REACH Status
Not registered yet.
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