INTRODUCTION
Niacinamide is a naturally occurring nutrient belonging to the pyridine carboxylic acid family. It is an important form of vitamin B3, an essential nutrient that supports many cellular processes and plays an important role in energy metabolism. Animal and refined grain-based products are fortified with Niacinamide.
It is a water-soluble vitamin that promotes release of energy from foods and enhances proper nervous system functioning. Along with systemic benefits, it also offers a wide range of topical benefits. Also, it is the preferred form of Vitamin B3 for treating Pellagra.
| Synonym | Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP, 3- Pyridinecarboxamide, Beta Pyridinecarboxamide |
| CAS no. | 98-92-0 |
| EINECS no. | 202-713-4 |
| Chemical Formula | C6H6N2O |
SPECIFICATIONS | Niacinamide Ph.Eur
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White or almost white crystalline powder or colorless crystals |
| pH | – | 6.0 – 7.5 |
| Assay on dried substance (Chemical – Titrimetic) | – | 99.0 – 101.0 |
| Loss on Drying | % w/w | Max 0.5 |
| Unspecified impurity | % | Max 0.10 |
| Total Impurities | % | Max 0.2 |
| Sulfated Ash | %w/w | Max 0.1 |
APPICATIONS
Common applications for niacinamide are in food, feed and beverages, health and personal care and the pharmaceutical industry. Niacinamide has several other health benefits and uses as follows:
HELPFUL FOR SKIN CARE & IN PREVENTING SKIN CANCER
Niacinamide plays an important role in keeping the skin healthy. For this reason, it’s a popular additive in the cosmetic and skincare industry. When applied topically or taken orally as a supplement, niacinamide has been shown to have anti-inflammatory effects on the skin. It has been used to treat skin conditions like acne and rosacea, a facial skin disorder characterized by redness.
t is also a promising supplement which may help in preventing Melanoma which is a serious type of skin cancer that develops in the cells that produce melanin, the pigment that gives your skin its color. Owing to its role in keeping your cells healthy, oral supplements of niacinamide have been shown to enhance DNA repair in UV damaged skin in humans.
THERAPEUTIC BENEFITS / USES
Chronic kidney disease is the progressive loss of kidney function which can cause a harmful buildup of chemicals.
Research suggests that niacinamide may help decrease phosphate levels in people with kidney dysfunction by blocking its absorption. It’s been suggested that niacinamide protects and preserves the beta cells, thereby preventing or delaying the onset of type 1 diabetes in at-risk individuals.
| INDUSTRY | APPLICATIONS |
|---|---|
| Food & Beverage | Nutrient supplement in foods such as dairy, breakfast cereals & infant formulas, as an additive in beverages, energy/health drinks |
| Health & Personal Care | Used in formulations of foundations, moisturizers, skin care products, lipsticks and eye shadows |
| Pharmaceuticals | Predominantly used as a dietary supplement & vitamin supplement in health drinks and also used in antipellagra factor drug |
| Animal Feed | Nutritional supplement in animal feed as well as pet food |
REGISTRATIONS / CERTIFICATIONS
| WHO-GMP |
| FAMI-QS |
| HACCP |
| Kosher |
| Halal |
PACKAGING OPTIONS
| Bulk Bags |
| HDPE/Fibre Drums |
STORAGE
Store in a sheltered place away from sources of heat and moisture.
Niacinamide is offered by ExSyn and is available for prompt delivery. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Nicotinamide riboside chloride (NRCL) is a unique form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, it has sparked interest in the realms of aging, metabolism, and overall cellular health.
Tetrachlorvinphos (popularly known as TCVP) is an agrochemical belonging to class of organophosphates. It is a non-systemic insecticide and acaracide having widespread uses in crop protection, public health, and animal hygiene.
Sodium Starch Glycolate (SSG) is a very fine free flowing powder that is white or off white in color and has almost no odor. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. It is a sodium salt of carboxyl ether of starch and is appreciated for its stability and binding properties.
3-([Ethyl(3-methylphenyl)amino]methyl) benzenesulfonic acid is an organic sulfonic acid, a white crystalline solid, which is widely used as a catalyst, acidifying agent, and a reagent in organic synthesis.
Sodium trifluoroacetate is a colorless organic solid belonging to category of fluoro compounds. It acts as a versatile trifluoromethylation agent in chemicals synthesis and is used to produce an array of chemical intermediates.
Iodopropynyl butylcarbamate, also known as IPBC, is an antimicrobial ingredient commonly used in cosmetics. It appears as a white, crystalline powder. It is not a paraben; it belongs to a different chemical class called carbamates. It is soluble in both water and oil-based systems. IPBC was invented in the 1970s and has a long history of effective use as an antifungal technology.
Stevia extract with Rebaudioside A (98%) is one of the sweet tasting steviol glycoside, extracted and purified from Stevia rebaudiana (Bertoni) – a small perennial shrub also known as “Honey leaf”. The leaves of S. rebaudiana contain more than 30 different steviol glycosides, among which stevioside and rebaudioside A are present in the highest levels. It is non-nutritive and tastes approximately 200-300 times sweeter than sucrose.
Protoporphyrin IX dimethyl ester, abbreviated PPMX, is an organic moiety belonging to category porphyrins. On exposure to light, PPMX releases reactive oxygen that can be used to destroy targeted cancer cells and thus it find applications largely in medicines.
Cetylpyridinium chloride is the chloride salt form of cetylpyridinium, a quaternary ammonium with broad-spectrum antimicrobial activity. Upon topical administration, cetylpyridinium chloride is positively charged and reacts with the negatively charged microbial cell surfaces, thereby destroying the integrity of the cell membrane.