INTRODUCTION

Sodium tert-butoxide is a stronger base (than primary and secondary alcoholates) and a non-nucleophilic base. It is flammable and moisture sensitive. It forms clusters in the solid state, both hexamers and nonamers, It is similar in reactivity to the more common potassium tert-butoxide.

Manufacture
The compound is produced by treating tert-butyl alcohol with sodium hydride.

SynonymsSodium t-butoxide
Sodium tert.-butylate
STB
NTB
CAS no.865-48-5
EINECS no.212-741-9
Molecular formulaC₄H₉ONa
Molecular weight96.10
Structure
APPLICATIONS
Sodium tert-butoxide is used as:

A promoter for the synthesis of biaryls by C-H bond arylation of aromatic compounds with haloarenes.

A base in palladium catalyzed amination reactions.

A base in the synthesis of aryl tert-butyl ethers from unactivated aryl halides in presence of palladium catalyst.

In the desulfonylation of N-indoles and N-azaindoles.

As a base in the synthesis of sodium acrylates from olefins and CO2.
It acts as a catalyst in polymerization and isomerization reactions.
In organic synthesis, it serves as an intermediate in various reactions like condensation, rearrangement and ring-opening.
Further, it finds use in agrochemicals, pharmaceuticals, colorants, aroma chemicals, detergents and biodiesel.

SPECIFICATIONS

TestUnitSpecification
AppearanceWhite to off-white powder
Total alkalinity (Calculated as NTB)% w/wMin 99.0
NaOH + Na2CO3
(Calculated as NaOH)
% w/wMax 1.0
Sodium-tert-butoxide (NTB)% w/wMin 97.0

PACKAGING
UN approved packing
– 100 gm to 500 gm for sample
– 1 kg
– 5 kg
– 10 kg (2 x 5 kg)
– 50 kg (10 x 5 kg)
– Any other packing as per customer request

STORAGE
NTB should be stored in a cool place away from heat, sparks and flame.

REACH Status
NTB offered by ExSyn is registered under EU REACH regulations.

No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

More Products
In focus: 2- (tert – Butylamino) Ethyl Methacrylate
Products in focus · 30/09/2025

2-(tert-Butyl amino)ethyl methacrylate (TBAEMA) is a functional methacrylate monomer that contains a secondary amine group and a hydrophobic tert-butyl moiety, giving it excellent versatility in pH-responsive and adhesion-enhancing polymer systems.
It is valued in printing ink formulations for its ability to enhance adhesion, flexibility, and surface interaction.

READ MORE
In focus: 1,1,2,2,3,3-Hexafluoropropane-1,3-disulfonimide Potassium Salt
Products in focus · 23/09/2025

Commonly known as potassium bis(fluorosulfonyl)imide (KFSI), the compound has a three-carbon backbone bearing six fluorine atoms and two sulfonimide (-SO₂F) groups. The molecule’s architecture lends it both high chemical stability and useful reactivity. Because of its excellent ionic conductivity and thermal / electrochemical stability, it finds use in advanced electrolyte formulations—for example in lithium-ion and next-generation batteries, in ionic liquids, and in other electrochemical systems.

READ MORE
In focus: Colchicine
Products in focus · 09/09/2025

Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.

READ MORE
In focus: 1-Butylimidazole
Products in focus · 02/09/2025

1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.

READ MORE
In focus: Atropine Sulfate, monohydrate
Products in focus · 26/08/2025

Atropine sulfate monohydrate is a chemical compound, specifically a salt of atropine and sulfuric acid, with one water molecule (monohydrate) attached. It is commonly used as a medication and in research due to its anticholinergic properties, meaning it blocks the effects of acetylcholine at muscarinic receptors.

READ MORE
In focus: 4-Aminobenzoic Acid (PABA)
Products in focus · 19/08/2025

4-Aminobenzoic acid, commonly abbreviated as PABA, is an aromatic amine and carboxylic acid compound. It consists of a benzene ring substituted with an amino group (–NH₂) in the para position to a carboxylic acid group (–COOH).

READ MORE
In focus: 2-Amino-5-Nitrophenol
Products in focus · 12/08/2025

2-Amino-5-Nitrophenol (5-NAP) is an organic compound with the molecular formula C₆H₆N₂O₃. It is a substituted phenol with both an amino group (-NH₂) and a nitro group (-NO₂) attached to a benzene ring, along with a hydroxyl group (-OH).

READ MORE
In focus: Pongamol Extract
Products in focus · 05/08/2025

Pongamol is a naturally occurring flavonoid primarily extracted from the seeds and leaves of the Pongamia pinnata tree (also known as Karanja tree), native to South and Southeast Asia. It is a cream-colored compound that belongs to the flavonoid family and is known for its antioxidant, anti-inflammatory, antimicrobial, and pesticidal properties. It is one of the key bioactive constituents of Pongamia oil.

READ MORE
In focus: Biobased Ethyl Acetate
Products in focus · 29/07/2025

Biobased Ethyl Acetate is an environmentally friendly solvent made from renewable sources like bioethanol extracted from sugarcane, corn, and other forms of biomass. Unlike traditional ethyl acetate, which is typically derived from fossil fuels, this green alternative shares the same chemical structure (C₄H₈O₂) and functional performance—offering comparable versatility with a significantly lower environmental footprint.

READ MORE