INTRODUCTION
n-Hexyllithium in hexane solution (HxLi) is an organolithium compound primarily used in organic synthesis as a strong base, alkylating agent, and lithiation reagent. It is particularly effective in the deprotonation of weakly acidic compounds. Handling n-Hexyllithium requires strict safety precautions due to its highly reactive nature, particularly due to its sensitivity to moisture, air, and heat.
MANUFACTURE
The manufacturing process typically involves the reaction of n-hexyl chloride (C6H13Cl) with a lithium metal in a hydrocarbon solvent, like hexane.
| Synonym | n-Hexyllithium, Hexane – lithium complex; 1-Lithiohexane |
| CAS no. | 21369-64-2 |
| EINECS no. | 404-950-0 |
| Molecular formula | CH3(CH2)5Li |
| Molecular weight | 92.11 |
| Structure |  |
APPLICATIONS
Due to its high reactivity, n-Hexyllithium is crucial in synthetic chemistry and helps in creating compounds used across various industries, including pharmaceuticals, agrochemicals, materials science, and polymer production.Some of the key applications for n-Hexyllithium are as follows;
| Nucleophilic substitution (formation of C-C bonds) |
| Grignard-like reactions with carbonyl compounds |
| Formation of organometallic intermediates for further synthesis |
| Lithiation of aromatic compounds for selective substitution |
| Synthesis of conjugated dienes and other specialized organic molecules |
| Polymerization initiation for synthetic rubbers or specialty plastics |
| Preparation of lithium enolates for carbonyl chemistry |
| Synthesis of organosilicon compounds |
| Regioselective lithiation for complex molecule synthesis |
| Reduction reactions involving electrophilic groups |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Pale yellow to dark yellow color liquid |
| Solubility | – | Soluble in Hexane and Tetrahydrofuran |
| Weight /mL (at 20°C) | gm /mL | 0.700 – 0.720 |
| Molarity | M | NLT 2.55 |
| Assay (Chemical Analysis) | % | NLT 33.0 |
STORAGE
Recommended storage temperature 2° to 8°C under inert gas. Air & moisture sensitive, hence store in airtight, moisture-resistant sealed containers. Shipped in reefer container.
PACKING
500 Ltrs. UN-approved cylinder.
REACH Status
Not registered.
ExSyn offers n-Hexyllithium in hexane solution on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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