INTRODUCTION

L-Phenylalanine (L-Phe) is an essential and  proteinogenic amino acid that helps build proteins and produces brain chemicals like dopamine and norepinephrine. L-Phenylalanine is one of the 20 standard amino acids that form long chains called polypeptides (proteins).The body cannot produce it, so it must be obtained through diet or supplements.

Manufacture

L-Phe is primarily produced through microbial fermentation using genetically engineered bacteria such as E. coli or Corynebacterium glutamicum. The bacteria are cultured in a nutrient-rich medium containing glucose, which they convert into L-Phenylalanine.

Synonyms(2S)-2-amino-3-phenylpropanoic acid ; 3-Phenyl-L-alanine; (S)-2-Amino-3-phenylpropionic acid ; H-Phe-OH; L-Phe
CAS no.63-91-2
EINECS no.200-568-1
Molecular formulaC9H11NO2
Molecular weight165.19
Structure

Applications

L-Phe  is widely used in various fields due to its role as an essential amino acid. It plays a key role in mood regulation, cognitive function, and overall nervous system health.

Protein Supplement
Used in dietary supplements as it’s an essential amino acid needed for protein synthesis
Precursor for Neurotransmitters
Converts into tyrosine, which is further used to make  dopamine, norepinephrine, and epinephrine —  important for mood, alertness, and stress response.
Food Industry (Aspartame Production)
A key ingredient in making L-Aspartame, a low-calorie artificial sweetener.
Treatment for Depression and ADHD                                                         
Sometimes used as a supplement to help manage symptoms.
Support in Skin Disorders (e.g., Vitiligo)
Studied for its role in melanin production when combined with UV light therapy.
Medical Nutrition    
Included in special medical foods for people with  metabolic disorders like PKU (Phenylketonuria) in a very controlled amounts.

SPECIFICATIONS

TestUnitSpecifications
AppearanceWhite crystals or crystalline powder
Identification (By IR)Should conform to the IR absorption of reference standard
Residue on ignition%NMT 0.4
Chloride (Cl)%NMT 0.05
Sulfate (SO4)%NMT 0.03
Iron (Fe)ppmNMT 30.0
Heavy MetalsppmNMT 15.0
Lead (Pb)ppmNMT 1.0
Related compounds
Individual Impurity%NMT 0.5
Total Impurities  %NMT 2.0
Specific rotation (αD25) °-32.7 to -34.7
pH5.4 – 6.0
Loss on drying%NMT 0.30
Total Plate Countcfu/gNMT 1000
Assay%98.5 – 101.5

STORAGE

Keep container tightly closed in a dry and well-ventilated place.

PACKING

35 Kgs & 50 Kgs HDPE drum.

REACH Status

Not registered

ExSyn offers L-Phenylalanine USP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

More Products
In focus: 5-Methyl-3-vinyl-2-oxazolidinone
Products in focus · 14/10/2025

5-Methyl-3-vinyl-2-oxazolidinone (V-MOX) is a highly reactive monomer valued for its low viscosity, mild odor, and excellent reactivity. It is widely used as a reactive diluent in UV-curable inks and coatings, where it enhances adhesion, produces brighter colors, and improves safety compared to conventional diluents. In addition, V-MOX serves as a key building block in the synthesis of kinetic hydrate inhibitor (KHI) polymers, which are applied in oil and gas production to prevent hydrate blockages in pipelines.

READ MORE
In focus: Zinc Ricinoleate
Products in focus · 07/10/2025

Zinc ricinoleate is the zinc salt of ricinoleic acid, a hydroxylated fatty acid derived mainly from castor oil (Ricinus communis). It appears as a white to slightly yellowish powder, waxy solid, or paste, depending on formulation. Its most valuable property is its ability to trap and absorb odor molecules such as amines, sulfides, and short-chain fatty acids, making it an essential ingredient in deodorant and odor-control products.

READ MORE
In focus: 2- (tert – Butylamino) Ethyl Methacrylate
Products in focus · 30/09/2025

2-(tert-Butyl amino)ethyl methacrylate (TBAEMA) is a functional methacrylate monomer that contains a secondary amine group and a hydrophobic tert-butyl moiety, giving it excellent versatility in pH-responsive and adhesion-enhancing polymer systems.
It is valued in printing ink formulations for its ability to enhance adhesion, flexibility, and surface interaction.

READ MORE
In focus: 1,1,2,2,3,3-Hexafluoropropane-1,3-disulfonimide Potassium Salt
Products in focus · 23/09/2025

Commonly known as potassium bis(fluorosulfonyl)imide (KFSI), the compound has a three-carbon backbone bearing six fluorine atoms and two sulfonimide (-SO₂F) groups. The molecule’s architecture lends it both high chemical stability and useful reactivity. Because of its excellent ionic conductivity and thermal / electrochemical stability, it finds use in advanced electrolyte formulations—for example in lithium-ion and next-generation batteries, in ionic liquids, and in other electrochemical systems.

READ MORE
In focus: Colchicine
Products in focus · 09/09/2025

Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.

READ MORE
In focus: 1-Butylimidazole
Products in focus · 02/09/2025

1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.

READ MORE
In focus: Atropine Sulfate, monohydrate
Products in focus · 26/08/2025

Atropine sulfate monohydrate is a chemical compound, specifically a salt of atropine and sulfuric acid, with one water molecule (monohydrate) attached. It is commonly used as a medication and in research due to its anticholinergic properties, meaning it blocks the effects of acetylcholine at muscarinic receptors.

READ MORE
In focus: 4-Aminobenzoic Acid (PABA)
Products in focus · 19/08/2025

4-Aminobenzoic acid, commonly abbreviated as PABA, is an aromatic amine and carboxylic acid compound. It consists of a benzene ring substituted with an amino group (–NH₂) in the para position to a carboxylic acid group (–COOH).

READ MORE
In focus: 2-Amino-5-Nitrophenol
Products in focus · 12/08/2025

2-Amino-5-Nitrophenol (5-NAP) is an organic compound with the molecular formula C₆H₆N₂O₃. It is a substituted phenol with both an amino group (-NH₂) and a nitro group (-NO₂) attached to a benzene ring, along with a hydroxyl group (-OH).

READ MORE