INTRODUCTION
4’-Cyanoacetophenone is an organic solid. It belongs to cyclic nitriles category. The presence of cyano group makes the compound reactive to form various intermediates and a few APIs. In organics syntheses, it also used as a catalyst.
Manufacture
It is manufactured by acetylation of benzonitrile with acetic anhydride in presence of a catalyst.
Synonym | 4-Acetylbenzonitrile 4-Cyanophenyl methyl ketone |
CAS no. | 1443-80-7 |
EINECS no. | 215-885-0 |
Molecular formula | C9H7NO |
Molecular weight | 145.16 |
Structure | ![]() |
Applications
API – The nitrile is a KRM for: |
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Ravuconazole, an anti-fungal |
Isovucanozole, also an anti-fungal |
Antimalarial isonitriles |
Some anesthetic and antiallergic agents |
Intermediates – It is also used in manufacture of intermediates such as: |
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4-(1,2,3-thiodiazyl-4-yl)benzoyl chloride |
4-(1,2,3-thiodiazyl-4-yl)benzonitrile |
(S)-1-(4-cyanophenyl)ethanamine |
4-Cyanophenylglyoxal hydrate |
1-Bromo-4-cyanoacetophenone |
4-Acetylbenozoic acid |
Others |
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As additive in fuel and lubricant formulations |
Uses in polymers and fragrances are cited in the literature |
SPECIFICATIONS
Test | Unit | Specifications |
---|---|---|
Appearance | – | Off-white to pale yellow crystalline powder |
Identification by IR | – | Should conform with standard |
Solubility | – | Soluble in methanol and chloroform |
Melting range | °C | 55.0 – 58.0 |
Loss on drying | % w/w | Max 0.50 |
Purity by GC | % área | Min 98.0 |
STORAGE
Stored at ambient temperature
PACKING
25 kg HDPE drum
REACH Status
Not registered
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