INTRODUCTION
2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.
Manufacture
The product is manufactured by ammonolysis of 2,6-difluorobenzonitrile.
Synonyms | 6-Fluoroanthranilonitrile 6-Fluoro-2-aminobenzonitrile |
CAS no. | 77326-36-4 |
EINECS no. | 616-451-7 |
Molecular formula | C7H5N2F |
Molecular weight | 136.13 |
Structure | ![]() |
Applications in Medicine
The halobenzonitrile is used to make medicinal products such as: |
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Novel Huprines |
Tacrine-related compounds |
Antifolates |
Applications in APIs
The nitrile acts as a KRM in production of APIs such as: |
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Pazopanib |
Dovitinib |
Dovitinib lactic acid salt |
Antibacterial quinazolines |
Applications in Intermediates
A few important intermediates are also synthesized from 6-fluoroanthranilonitrile: |
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(4-Oxoquinazolin-2-yl)pyridine |
2-Amino-6-bromobenzonitrile |
N-(2-cyano-3-fluorophenyl)pyrrole |
2-Fluoro-6-piperidinobenzonitrile |
2-Amino-6-fluorobenzoic acid |
5-Fluoro-1H-quinazoline-2,4-dione |
5-Fluoro-2,4-diaminoquinazoline |
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | Grey to light yellow solid |
Purity | % | Min 99.0 |
Moisture | % | Max 0.5 |
Melting Range | °C | 120.0 – 128.0 |
STORAGE
The product is stored at ambient temperature
PACKING
25 kg drum
REACH Status
Not registered yet
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